James Mason

Publications

• Antimicrobial Peptide Potency is Facilitated by Greater Conformational Flexibility when Binding to Gram-negative Bacterial Inner Membranes
• Cervicovaginal microbiota and metabolome predict preterm birth risk in an ethnically diverse cohort
• Nuclear Magnetic Resonance Metabolomics of Symbioses between Bacterial Vaginosis-Associated Bacteria
• Divergent Relationships between Fecal Microbiota and Metabolome following Distinct Antibiotic-Induced Disruptions
• Cationic amphipathic D-enantiomeric antimicrobial peptides with in vitro and ex vivo activity against drug-resistant Mycobacterium tuberculosis
• Temporin B Forms Hetero-Oligomers with Temporin L, Modifies Its Membrane Activity, and Increases the Cooperativity of Its Antibacterial Pharmacodynamic Profile
• Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity
• Erratum to: Antimicrobial Peptide Potency is Facilitated by Greater Conformational Flexibility when Binding to Gram-negative Bacterial Inner Membranes (Scientific Reports, (2016), 6, 1, (37639), 10.1038/srep37639)
• Temporin L and aurein 2.5 have identical conformations but subtly distinct membrane and antibacterial activities
• The influence of rough lipopolysaccharide structure on molecular interactions with mammalian antimicrobial peptides.
• Inhalable spray-dried formulation of D-LAK antimicrobial peptides targeting tuberculosis
• Modification of KL4 Peptide Revealed the Importance of Alpha-Helical Structure for Efficient siRNA Delivery
• A Pleurocidin Analogue with Greater Conformational Flexibility, Enhanced Antimicrobial Potency and in vivo Therapeutic Efficacy
• Bolaamphiphile analogues of 12-bis-THA Cl2 are potent antimicrobial therapeutics with distinct mechanisms of action against bacterial, mycobacterial, and fungal pathogens
• Development of Cationic Lipid LAH4-L1 siRNA Complexes for Focused Ultrasound Enhanced Tumor Uptake
• NMR metabolomics of symbioses between bacterial vaginosis associated bacteria
• Pseudomonas aeruginosa adapts to octenidine via a combination of efflux and membrane remodelling
• Temporin B forms hetero-oligomers with Temporin L, modifies its membrane activity and increases the cooperativity of its antibacterial pharmacodynamic profile
• New Techniques to Assess In Vitro Release of siRNA from Nanoscale Polyplexes
• Inhalable Dry Powder Formulations of siRNA and pH-Responsive Peptides with Antiviral Activity Against H1N1 Influenza Virus
• Incorporation of a nuclear localization signal in pH responsive LAH4-L1 peptide enhances transfection and nuclear uptake of plasmid DNA
• Histidine-rich designer peptides of the LAH4 family promote cell delivery of a multitude of cargo
• Histidine-rich cationic cell-penetrating peptides for plasmid DNA and siRNA delivery
• Cationic antimicrobial peptides do not change recombination frequency in Escherichia coli
• Rifampicin or capreomycin induced remodelling of the Mycobacterium smegmatis mycolic acid layer is mitigated in synergistic combinations with cationic antimicrobial peptides
• Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity
• Opportunistic bacteria confer the ability to ferment prebiotic starch in the adult cystic fibrosis gut
• Low FODMAP diet & prebiotic β-galactooligosaccharides improve irritable bowel syndrome and response to low FODMAP is predicted by urine and faecal metabolites
• α-Amylase action on starch in chickpea flour following hydrothermal processing and different drying, cooling and storage conditions
• Optimization of PEGylated KL4 Peptide for siRNA Delivery with Improved Pulmonary Tolerance
• Development of Novel Membrane Disrupting Lipoguanidine Compounds Sensitizing Gram-Negative Bacteria to Antibiotics
• Parallel evolution of frog antimicrobial peptides produces identical conformations but subtly distinct membrane and antibacterial activities
• Tryptophan End-Tagging Confers Antifungal Activity on a Tick-Derived Peptide by Triggering Reactive Oxygen Species Production
• Single-cell RNA-sequencing and Metabolomics Analyses Reveal the Contribution of Perivascular Adipose Tissue Stem Cells to Vascular Remodeling
• Synthetic antimicrobial peptide tuning permits membrane disruption and interpeptide synergy
• β-Galactooligosaccharide in Conjunction With Low FODMAP Diet Improves Irritable Bowel Syndrome Symptoms but Reduces Fecal Bifidobacteria
• Impacts of metabolism and organic acids on cell wall composition and Pseudomonas aeruginosa susceptibility to membrane active antimicrobials
• Design of a new cell penetrating peptide for DNA, siRNA and mRNA delivery
• Neutrophils Dominate the Cervical Immune Cell Population in Pregnancy and Their Transcriptome Correlates With the Microbial Vaginal Environment
• Design and manufacture of a lyophilised faecal microbiota capsule formulation to GMP standards
• Synergy between Winter Flounder Antimicrobial Peptides
• Characterising the chemical and physical properties of phase-change nanodroplets
• The impact of long-term macrolide exposure on the gut microbiome and its implications for metabolic control
• Faecal and urine metabolites, but not gut microbiota, may predict response to low FODMAP diet in irritable bowel syndrome
• Fibrous matrices facilitate pleurocidin killing of wound associated bacterial pathogens
• QSAR reveals decreased lipophilicity of polar residues determines the selectivity of antimicrobial peptide activity
• Synergistic combination of antimicrobial peptide and isoniazid as inhalable dry powder formulation against multi-drug resistant tuberculosis
• Emergent conformational and aggregation properties of synergistic antimicrobial peptide combinations
• Construction of a drug sensitisedCandida aurisstrain
• Biochar filtration of drug-resistant bacteria and active pharmaceutical ingredients to combat antimicrobial resistance
• Observations of light-induced structural changes of retinal within rhodopsin
• A relationship between Pseudomonal growth behaviour and cystic fibrosis patient lung function identified in a metabolomic investigation
• Manipulating the pH response of 2,3-diaminopropionic acid rich peptides to mediate highly effective gene silencing with low-toxicity
• Membrane-disordering in the presence of antimicrobial peptides by 2H solid-state NMR spectroscopy
• Identifying anisotropic constraints in multiply labelled Bacteriorhodopsin by 15N MAOSS NMR: A general approach to structural studies of membrane proteins
• Conformational heterogeneity of transmembrane residues after the Schiff base reprotonation of bacteriorhodopsin, as seen by 15N CPMAS NMR of D85N/T170C membranes
• Control of pH responsive peptide self-association during endocytosis is required for effective gene transfer
• Incorporation of 2,3-Diaminopropionic Acid into Linear Cationic Amphipathic Peptides Produces pH-Sensitive Vectors
• Membrane interaction of chrysophsin-1, a histidine-rich antimicrobial peptide from red sea bream
• Aggregation and membrane permeabilizing properties of designed histidine-containing cationic linear peptide antibiotics
• Amino acid type selective isotope labelling of the multidrug ABC transporter LmrA for solid-state NMR studies
• Cationic amphipathic histidine-rich peptides for gene delivery
• Conformational Flexibility Determines Selectivity and Antibacterial, Antiplasmodial, and Anticancer Potency of Cationic alpha-Helical Peptides
• A spectroscopic study of the membrane interaction of the antimicrobial peptide pleurocidin
• A spectroscopic study of the membrane interaction of tuberoinfundibular peptide of 39 residues (TIP39)
• Conformational heterogeneity of transmembrane residues after the Schiff base reprotonation of bacteriorhodopsin - N-15 CPMAS NMR of D85N/T170C membranes
• Design and Evaluation of Histidine-Rich Amphipathic Peptides for siRNA Delivery
• Deuterium-MAS NMR spectroscopy on oriented membrane proteins: Applications to photointermediates of bacteriorhodopsin
• Enhanced membrane disruption and antibiotic action against pathogenic bacteria by designed histidine-rich peptides at acidic pH
• Identifying anisotropic constraints in multiply labeled bacteriorhodopsin by N-15 MAOSS NMR: A general approach to structural studies of membrane proteins
• Lipid-Peptide Vesicle Nanoscale Hybrids for Triggered Drug Release by Mild Hyperthermia in Vitro and in Vivo
• Effective endogenous gene silencing mediated by pH responsive peptides proceeds via multiple pathways
• How to prepare membrane proteins for solid-state NMR: A case study on the cc-helical integral membrane protein diacylglycerol kinase from E-coli
• Structural and orientational constraints of bacteriorhodopsin in purple membranes determined by oriented-sample solid-state NMR spectroscopy
• Membrane order perturbation in the presence of antimicrobial peptides by H-2 solid-state NMR spectroscopy
• Observations of light-induced structural changes of retinal within rhodopsin
• Optimising histidine rich peptides for efficient DNA delivery in the presence of serum
• Structural Determinants of Antimicrobial and Antiplasmodial Activity and Selectivity in Histidine-rich Amphipathic Cationic Peptides
• Zwitterionic phospholipids and sterols modulate antimicrobial peptide-induced membrane destabilization
• NMR Metabolomics of MTLn3E Breast Cancer Cells Identifies a Role for CXCR4 in Lipid and Choline Regulation
• Rational design of vector and antibiotic peptides using solid-state NMR
• Separated local field NMR experiments on oriented samples rotating at the magic angle
• Structural contributions to the intracellular targeting strategies of antimicrobial peptides
• The antibiotic and DNA-transfecting peptide LAH4 selectively associates with, and disorders, anionic lipids in mixed membranes
• Functional divergence in gastrointestinal microbiota in physically-separated genetically identical mice
• Combined Systems Approaches Reveal Highly Plastic Responses to Antimicrobial Peptide Challenge in Escherichia coli
• Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids
• Observations of light-induced structural changes of retinal within rhodopsin
• Histidine-rich cationic amphipathic peptides for plasmid DNA and siRNA delivery
• Histidine-rich cationic amphipathic peptides for plasmid DNA and siRNA delivery.
• Identifying Anistropic Constraints in Multiply Labeled Bacteriorhodopsin by 15N MAOSS NMR: A General Approach to Structural Studies of Membrane Proteins
• Western blot evaluation of siRNA delivery by ph-responsive peptides
• Carboxy-Amidated AamAP1-Lys has Superior Conformational Flexibility and Accelerated Killing of Gram-Negative Bacteria
• Improving the Activity and Selectivity of a Scorpion-Derived Peptide, A3a, against Acinetobacter baumannii through Rational Design
• Metabolism ofLactobacillusandGardnerella vaginalisin vaginal defined media
• Enhanced Gram-Negative Membrane Disruption and In Vivo Efficacy via Lysine-Arginine Enrichment of Opis16a
• Bacterial diversity, viability and stability in lyophilised faecal microbiota capsules support ongoing clinical use