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James Fleckenstein

Publications

  • The Intriguing Interaction of Escherichia coli with the Host Environment and Innovative Strategies To Interfere with Colonization: a Summary of the 2019 E. coli and the Mucosal Immune System Meeting
  • Blood Group O-Dependent Cellular Responses to Cholera Toxin: Parallel Clinical and Epidemiological Links to Severe Cholera.
  • Examination of the Enterotoxigenic Escherichia coli Population Structure during Human Infection
  • Insights into enterotoxigenic Escherichia coli diversity in Bangladesh utilizing genomic epidemiology
  • Overcoming Enterotoxigenic Escherichia coli Pathogen Diversity: Translational Molecular Approaches to Inform Vaccine Design.
  • Digestive System Infections
  • Confronting Challenges to Enterotoxigenic Escherichia coli Vaccine Development
  • Changing the locks on intestinal signaling.
  • Acute Bacterial Gastroenteritis.
  • Vaccines for Protecting Infants from Bacterial Causes of Diarrheal Disease.
  • Spontaneous Bacterial Peritonitis Caused by Bordetella hinzii.
  • Emerging Themes in the Molecular Pathogenesis of Enterotoxigenic Escherichia coli.
  • Contribution of Noncanonical Antigens to Virulence and Adaptive Immunity in Human Infection with Enterotoxigenic E. coli.
  • Effect of chronic alcohol exposure on gut vitamin B7 uptake: involvement of epigenetic mechanisms and effect of alcohol metabolites.
  • Structural and biophysical characterization of the secreted, β-helical adhesin EtpA of Enterotoxigenic Escherichia coli
  • A role for salivary peptides in the innate defense against enterotoxigenic Escherichia coli
  • Enterotoxigenic escherichia coli secretes a highly conserved mucin-degrading metalloprotease to effectively engage intestinal epithelial cells
  • Eata, an immunogenic protective antigen of enterotoxigenic escherichia coli, degrades intestinal mucin
  • Transcriptional modulation of enterotoxigenic Escherichia coli virulence genes in response to epithelial cell interactions
  • Enterotoxigenic Escherichia coli: Orchestrated host engagement
  • Cooperative role of antibodies against heat-labile toxin and the EtpA adhesin in preventing toxin delivery and intestinal colonization by enterotoxigenic Escherichia coli
  • Conservation and Immunogenicity of Novel Antigens in Diverse Isolates of Enterotoxigenic Escherichia coli
  • Contribution of the highly conserved EaeH surface protein to enterotoxigenic Escherichia coli pathogenesis
  • Designing vaccines to neutralize effective toxin delivery by enterotoxigenic Escherichia coli
  • Enterotoxigenic Escherichia coli: Orchestrated host engagement.
  • Digestive system infections
  • Blood Group O-Dependent cellular responses to cholera toxin: Parallel clinical and epidemiological links to severe cholera
  • Overcoming enterotoxigenic Escherichia coli pathogen diversity: Translational molecular approaches to inform vaccine design
  • Comparative genomics and transcriptomics of Escherichia coli isolates carrying virulence factors of both enteropathogenic and enterotoxigenic E. coli
  • Characterization of enterotoxigenic Escherichia coli strains isolated from the massive multi-pathogen gastroenteritis outbreak in the Antofagasta region following the Chilean earthquake, 2010
  • Enterotoxigenic Escherichia coli Infections
  • Human experimental challenge with enterotoxigenic Escherichia coli elicits immune responses to canonical and novel antigens relevant to vaccine development
  • Providing Structure to Enterotoxigenic Escherichia coli Vaccine Development
  • Erratum: Enterotoxigenic Escherichia coli-blood group a interactions intensify diarrheal severity (Journal of Clinical Investigation (2018)128(8)(3298-3311)Doi:10.1172/JCI97659)
  • Interrogation of a live-attenuated enterotoxigenic Escherichia coli vaccine highlights features unique to wild-type infection
  • Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity
  • How genomics can be used to understand host susceptibility to enteric infection, aiding in the development of vaccines and immunotherapeutic interventions
  • Immunogenicity and Protective Efficacy against Enterotoxigenic Escherichia coli Colonization following Intradermal, Sublingual, or Oral Vaccination with EtpA Adhesin
  • Escherichia coli sequence type 131 (ST131) subclone H30 as an emergent multidrug-resistant pathogen among US veterans.
  • Dynamic Interactions of a Conserved Enterotoxigenic Escherichia coli Adhesin with Intestinal Mucins Govern Epithelium Engagement and Toxin Delivery
  • Novel antigens for enterotoxigenic Escherichia coli vaccines
  • Enterotoxigenic Escherichia coli
  • Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions
  • Molecular determinants of enterotoxigenic Escherichia coli heat-stable toxin secretion and delivery
  • Molecular Determinants of Enterotoxigenic Escherichia coli Heat-Stable Toxin Secretion and Delivery
  • Mechanical Stimuli Affect E. Coli Heat Stable Enterotoxin (ST)-Cyclic GMP Signaling in a Human Enteroid Intestine-Chip Diarrhea Model
  • Comparative genomic analysis and molecular examination of the diversity of enterotoxigenic Escherichia coli isolates from Chile
  • Mechanical Stimuli Affect Escherichia coli Heat-Stable Enterotoxin-Cyclic GMP Signaling in a Human Enteroid Intestine-Chip Model
  • Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection
  • CEACAMs serve as toxin-stimulated receptors for enterotoxigenic Escherichia coli
  • Diseases Transmitted by Food, Water, and Soil
  • Characterization of enterotoxigenic Escherichia coli strains isolated from the massive multi-pathogen gastroenteritis outbreak in the Antofagasta region following the Chilean earthquake, 2010.
  • Cryptococcal skull infection: A case report with review of the literature
  • Outer membrane vesicles induce immune responses to virulence proteins and protect against colonization by enterotoxigenic Escherichia coli
  • Directed evaluation of enterotoxigenic escherichia coli autotransporter proteins as putative vaccine candidates
  • Adhesin degradation accelerates delivery of heat-labile toxin by enterotoxigenic Escherichia coli
  • Molecular mechanisms of enterotoxigenic Escherichia coli infection
  • Lingual leishmaniasis complicating visceral disease
  • Heat-labile enterotoxin promotes Escherichia coli adherence to intestinal epithelial cells
  • Enterotoxigenic Escherichia coli EtpA mediates adhesion between flagella and host cells
  • Enterotoxigenic Escherichia coli elicits immune responses to multiple surface proteins
  • Purification of recombinant high molecular weight two-partner secretion proteins from Escherichia coli
  • Identification of a two-partner secretion locus of enterotoxigenic Escherichia coli
  • The EtpA exoprotein of enterotoxigenic Escherichia coli promotes intestinal colonization and is a protective antigen in an experimental model of murine infection
  • Interaction of an outer membrane protein of enterotoxigenic Escherichia coli with cell surface heparan sulfate proteoglycans
  • Identification of a gene within a pathogenicity island of enterotoxigenic Escherichia coli H10407 required for maximal secretion of the heat-labile enterotoxin
  • Molecular characterization of the tia invasion locus from enterotoxigenic Escherichia coli
  • Importance of heat-labile enterotoxin in colonization of the adult mouse small intestine by human enterotoxigenic Escherichia coli strains
  • Identification and Molecular Characterization of EatA, An Autotransporter Protein of Enterotoxigenic Escherichia coli
  • Breaching the mucosal barrier by stealth: An emerging pathogenic mechanism for enteroadherent bacterial pathogens
  • Incidental discovery of emphysematous cystitis
  • Digestive system infections
  • Incidental Discovery of Emphysematous Cystitis
  • Cryptococcal Skull Infection
  • Vaccination with EtpA glycoprotein or flagellin protects against colonization with enterotoxigenic Escherichia coli in a murine model
  • Directed delivery of heat-labile enterotoxin by enterotoxigenic Escherichia coli
  • Breaching the mucosal barrier by stealth: an emerging pathogenic mechanism for enteroadherent bacterial pathogens
  • Infectious Agents of Food- and Water-Borne Illnesses

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Co-workers & collaborators

Alaullah Sheikh

Alaullah Sheikh

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