James Fleckenstein

Publications

• The Intriguing Interaction of Escherichia coli with the Host Environment and Innovative Strategies To Interfere with Colonization: a Summary of the 2019 E. coli and the Mucosal Immune System Meeting
• Blood Group O-Dependent Cellular Responses to Cholera Toxin: Parallel Clinical and Epidemiological Links to Severe Cholera.
• Examination of the Enterotoxigenic Escherichia coli Population Structure during Human Infection
• Insights into enterotoxigenic Escherichia coli diversity in Bangladesh utilizing genomic epidemiology
• Overcoming Enterotoxigenic Escherichia coli Pathogen Diversity: Translational Molecular Approaches to Inform Vaccine Design.
• Digestive System Infections
• Confronting Challenges to Enterotoxigenic Escherichia coli Vaccine Development
• Changing the locks on intestinal signaling.
• Acute Bacterial Gastroenteritis.
• Vaccines for Protecting Infants from Bacterial Causes of Diarrheal Disease.
• Spontaneous Bacterial Peritonitis Caused by Bordetella hinzii.
• Emerging Themes in the Molecular Pathogenesis of Enterotoxigenic Escherichia coli.
• Contribution of Noncanonical Antigens to Virulence and Adaptive Immunity in Human Infection with Enterotoxigenic E. coli.
• Effect of chronic alcohol exposure on gut vitamin B7 uptake: involvement of epigenetic mechanisms and effect of alcohol metabolites.
• Structural and biophysical characterization of the secreted, β-helical adhesin EtpA of Enterotoxigenic Escherichia coli
• A role for salivary peptides in the innate defense against enterotoxigenic Escherichia coli
• Enterotoxigenic escherichia coli secretes a highly conserved mucin-degrading metalloprotease to effectively engage intestinal epithelial cells
• Eata, an immunogenic protective antigen of enterotoxigenic escherichia coli, degrades intestinal mucin
• Transcriptional modulation of enterotoxigenic Escherichia coli virulence genes in response to epithelial cell interactions
• Enterotoxigenic Escherichia coli: Orchestrated host engagement
• Cooperative role of antibodies against heat-labile toxin and the EtpA adhesin in preventing toxin delivery and intestinal colonization by enterotoxigenic Escherichia coli
• Conservation and Immunogenicity of Novel Antigens in Diverse Isolates of Enterotoxigenic Escherichia coli
• Contribution of the highly conserved EaeH surface protein to enterotoxigenic Escherichia coli pathogenesis
• Designing vaccines to neutralize effective toxin delivery by enterotoxigenic Escherichia coli
• Enterotoxigenic Escherichia coli: Orchestrated host engagement.
• Digestive system infections
• Blood Group O-Dependent cellular responses to cholera toxin: Parallel clinical and epidemiological links to severe cholera
• Overcoming enterotoxigenic Escherichia coli pathogen diversity: Translational molecular approaches to inform vaccine design
• Comparative genomics and transcriptomics of Escherichia coli isolates carrying virulence factors of both enteropathogenic and enterotoxigenic E. coli
• Characterization of enterotoxigenic Escherichia coli strains isolated from the massive multi-pathogen gastroenteritis outbreak in the Antofagasta region following the Chilean earthquake, 2010
• Enterotoxigenic Escherichia coli Infections
• Human experimental challenge with enterotoxigenic Escherichia coli elicits immune responses to canonical and novel antigens relevant to vaccine development
• Providing Structure to Enterotoxigenic Escherichia coli Vaccine Development
• Erratum: Enterotoxigenic Escherichia coli-blood group a interactions intensify diarrheal severity (Journal of Clinical Investigation (2018)128(8)(3298-3311)Doi:10.1172/JCI97659)
• Interrogation of a live-attenuated enterotoxigenic Escherichia coli vaccine highlights features unique to wild-type infection
• Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity
• How genomics can be used to understand host susceptibility to enteric infection, aiding in the development of vaccines and immunotherapeutic interventions
• Immunogenicity and Protective Efficacy against Enterotoxigenic Escherichia coli Colonization following Intradermal, Sublingual, or Oral Vaccination with EtpA Adhesin
• Escherichia coli sequence type 131 (ST131) subclone H30 as an emergent multidrug-resistant pathogen among US veterans.
• Dynamic Interactions of a Conserved Enterotoxigenic Escherichia coli Adhesin with Intestinal Mucins Govern Epithelium Engagement and Toxin Delivery
• Novel antigens for enterotoxigenic Escherichia coli vaccines
• Enterotoxigenic Escherichia coli
• Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions
• Molecular determinants of enterotoxigenic Escherichia coli heat-stable toxin secretion and delivery
• Molecular Determinants of Enterotoxigenic Escherichia coli Heat-Stable Toxin Secretion and Delivery
• Mechanical Stimuli Affect E. Coli Heat Stable Enterotoxin (ST)-Cyclic GMP Signaling in a Human Enteroid Intestine-Chip Diarrhea Model
• Comparative genomic analysis and molecular examination of the diversity of enterotoxigenic Escherichia coli isolates from Chile
• Mechanical Stimuli Affect Escherichia coli Heat-Stable Enterotoxin-Cyclic GMP Signaling in a Human Enteroid Intestine-Chip Model
• Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection
• CEACAMs serve as toxin-stimulated receptors for enterotoxigenic Escherichia coli
• Diseases Transmitted by Food, Water, and Soil
• Characterization of enterotoxigenic Escherichia coli strains isolated from the massive multi-pathogen gastroenteritis outbreak in the Antofagasta region following the Chilean earthquake, 2010.
• Cryptococcal skull infection: A case report with review of the literature
• Outer membrane vesicles induce immune responses to virulence proteins and protect against colonization by enterotoxigenic Escherichia coli
• Directed evaluation of enterotoxigenic escherichia coli autotransporter proteins as putative vaccine candidates
• Adhesin degradation accelerates delivery of heat-labile toxin by enterotoxigenic Escherichia coli
• Molecular mechanisms of enterotoxigenic Escherichia coli infection
• Lingual leishmaniasis complicating visceral disease
• Heat-labile enterotoxin promotes Escherichia coli adherence to intestinal epithelial cells
• Enterotoxigenic Escherichia coli EtpA mediates adhesion between flagella and host cells
• Enterotoxigenic Escherichia coli elicits immune responses to multiple surface proteins
• Purification of recombinant high molecular weight two-partner secretion proteins from Escherichia coli
• Identification of a two-partner secretion locus of enterotoxigenic Escherichia coli
• The EtpA exoprotein of enterotoxigenic Escherichia coli promotes intestinal colonization and is a protective antigen in an experimental model of murine infection
• Interaction of an outer membrane protein of enterotoxigenic Escherichia coli with cell surface heparan sulfate proteoglycans
• Identification of a gene within a pathogenicity island of enterotoxigenic Escherichia coli H10407 required for maximal secretion of the heat-labile enterotoxin
• Molecular characterization of the tia invasion locus from enterotoxigenic Escherichia coli
• Importance of heat-labile enterotoxin in colonization of the adult mouse small intestine by human enterotoxigenic Escherichia coli strains
• Identification and Molecular Characterization of EatA, An Autotransporter Protein of Enterotoxigenic Escherichia coli
• Breaching the mucosal barrier by stealth: An emerging pathogenic mechanism for enteroadherent bacterial pathogens
• Incidental discovery of emphysematous cystitis
• Digestive system infections
• Incidental Discovery of Emphysematous Cystitis
• Cryptococcal Skull Infection
• Vaccination with EtpA glycoprotein or flagellin protects against colonization with enterotoxigenic Escherichia coli in a murine model
• Directed delivery of heat-labile enterotoxin by enterotoxigenic Escherichia coli
• Breaching the mucosal barrier by stealth: an emerging pathogenic mechanism for enteroadherent bacterial pathogens
• Infectious Agents of Food- and Water-Borne Illnesses
• Interactions of pathogenic Escherichia coli with CEACAMs.
• Parenteral Vaccination with recombinant EtpA glycoprotein impairs enterotoxigenic E. coli colonization
• Degradation of the intestinal mucus layer by the ETEC protease EatA is species specific determined by the structure of the MUC2 mucin
• Parenteral vaccination with recombinant EtpA glycoprotein impairs enterotoxigenic E. coli colonization