Hanieh Yaghootkar

Publications

• Estimating the Effect of Liver and Pancreas Volume and Fat Content on Risk of Diabetes: A Mendelian Randomization Study
• Ethnic Differences in Body Fat Deposition and Liver Fat Content in Two UK-Based Cohorts
• Higher maternal adiposity reduces offspring birthweight if associated with a metabolically favourable profile
• Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use
• Machine Learning based histology phenotyping to investigate epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits
• Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits
• Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: A Mendelian randomization study
• Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile
• Corrigendum to: “Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis” [J Hepatol (2020) 241-251] (Journal of Hepatology (2020) (241-251) (S016882782030194X), (10.1016/j.jhep.2020.03.032))
• Refining Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Genetic Loci by Integrating Summary Data From Genome-wide Association, Gene Expression, and DNA Methylation Studies
• Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
• Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight
• Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile
• A case of H syndrome with a novel mutation in SLC29A3
• rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis
• Identification of 370 loci for age at onset of sexual and reproductive behaviour, highlighting common aetiology with reproductive biology, externalizing behaviour and longevity
• Coding Variant in LEP Associated with Lower Leptin Concentrations Implicates Leptin in the Regulation of Early Adiposity
• Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease
• rs641738C>T near MBOAT7 is positively associated with liver fat, ALT, and histological severity of NAFLD: A meta-analysis
• Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration.
• Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology.
• Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology.
• The Māori and Pacific specific CREBRF variant and adult height.
• Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis.
• A Mendelian Randomization Study Provides Evidence that Adiposity and Dyslipidemia Lead to Lower Urinary Albumin Creatinine Ratio, a Marker of Microvascular Function.
• Response to Prakash et al.
• Using genetics to understand the causal influence of higher BMI on depression.
• Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
• Wolcott-Rallison syndrome in Iran: a common cause of neonatal diabetes.
• Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.
• Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.
• Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour.
• Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
• Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms.
• Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances.
• Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension.
• Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
• Mosaic Turner syndrome shows reduced penetrance in an adult population study.
• DNA methylation and inflammation marker profiles associated with a history of depression.
• A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure.
• Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
• Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
• Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics.
• Using genetics to decipher the link between type 2 diabetes and cancer: shared aetiology or downstream consequence?
• Type 1 diabetes genetic risk score discriminates between monogenic and Type 1 diabetes in children diagnosed at the age of <5 years in the Iranian population
• Advancing a causal role of type 2 diabetes and its components in developing macro‐ and microvascular complications via genetic studies
• Ethnic differences in adiposity and diabetes risk – insights from genetic studies
• Machine Learning based histology phenotyping to investigate the epidemiologic and genetic basis of adipocyte morphology and cardiometabolic traits
• Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity
• Differing genetic variants associated with liver fat and their contrasting relationships with cardiovascular diseases and cancer
• Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood
• Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
• Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
• Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease
• Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes
• Meta-analysis of genome-wide association studies for body fat distribution in 694,649 individuals of European ancestry
• Erratum: Common variants at 12q15 and 12q24 are associated with infant head circumference (Nature Genetics (2012) 44 (532-538))
• Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis
• Protein-coding variants implicate novel genes related to Lipid homeostasis contributing to body fat distribution
• Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour
• Red Blood Cell Distribution Width: Genetic evidence for aging pathways in 116,666 volunteers
• A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure
• Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty
• Mosaic Turner syndrome shows reduced phenotypic penetrance in an adult population study compared to clinically ascertained cases
• New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
• Testing the role of predicted gene knockouts in human anthropometric trait variation.
• Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health.
• Cell Specific eQTL Analysis without Sorting Cells.
• Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes.
• Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
• Exome-wide association study of plasma lipids in >300,000 individuals.
• CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits.
• Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.
• Rare and low-frequency coding variants alter human adult height.
• Corrigendum: Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.
• Recent progress in the use of genetics to understand links between type 2 diabetes and related metabolic traits.
• Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
• Gene-obesogenic environment interactions in the UK Biobank study.
• Quantifying the extent to which index event biases influence large genetic association studies.
• Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.
• Genome-wide associations for birth weight and correlations with adult disease.
• Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.
• Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci.
• Analysis with the exome array identifies multiple new independent variants in lipid loci.
• Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease.
• A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.
• Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants.
• Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.
• Functional characterisation of ADIPOQ variants using individuals recruited by genotype.
• Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.
• The transcriptional landscape of age in human peripheral blood.
• Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes.
• Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank.
• Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion.
• A genetic variant in the seed region of miR-4513 shows pleiotropic effects on lipid and glucose homeostasis, blood pressure, and coronary artery disease.
• Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity.
• Tumor necrosis factor-alpha polymorphism at position -238 in preeclampsia.
• Parental diabetes and birthweight in 236 030 individuals in the UK biobank study.
• Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes.
• Systematic identification of trans eQTLs as putative drivers of known disease associations.
• A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
• Common variants at 12q15 and 12q24 are associated with infant head circumference.
• Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.
• Genetic origins of low birth weight.
• Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association.
• Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing.
• Association between serum CRP concentrations with dietary intake in healthy and dyslipidaemic patients.
• Newly detected hypertension in an Iranian population: An epidemiological study
• Association between serum CRP concentrations with dietary intake in healthy and dyslipidaemic patients