Gerard Sergeant

Publications

• Investigation of L-type Ca(2+) current in the aganglionic bowel segment in Hirschsprung's disease.
• Blockade of Kv7 channels reverses the inhibitory effects of exchange protein directly activated by cAMP activation on purinergic contractions of the murine detrusor
• Contribution of Postjunctional M2 Muscarinic Receptors to Cholinergic Nerve-Mediated Contractions of Murine Airway Smooth Muscle
• M2 Muscarinic Receptor-Dependent Contractions of Airway Smooth Muscle are Inhibited by Activation of β-Adrenoceptors
• Muscarinic receptor-induced contractions of the detrusor are impaired in TRPC4 deficient mice
• The role of cAMP dependent protein kinase in modulating spontaneous intracellular Ca²⁺ waves in interstitial cells of Cajal from the rabbit urethra.
• Development of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels.
• The effect of high [K(+)]o on spontaneous Ca(2+) waves in freshly isolated interstitial cells of Cajal from the rabbit urethra.
• ATP evokes inward currents in corpus cavernosum myocytes.
• Mechanisms underlying activation of transient BK current in rabbit urethral smooth muscle cells and its modulation by IP3-generating agonists.
• The cardiac sodium current Na(v)1.5 is functionally expressed in rabbit bronchial smooth muscle cells.
• Effects of phenylephrine on spontaneous activity and L-type Ca2+ current in isolated corpus cavernosum myocytes.
• Structure-activity relationships of a novel group of large-conductance Ca(2+)-activated K(+) (BK) channel modulators: the GoSlo-SR family.
• Platelet-derived growth factor receptor-α cells in mouse urinary bladder: a new class of interstitial cells.
• Cajal beyond the gut: interstitial cells in the urinary system--towards general regulatory mechanisms of smooth muscle contractility?
• Contribution of Kv2.1 channels to the delayed rectifier current in freshly dispersed smooth muscle cells from rabbit urethra.
• P2X receptor currents in smooth muscle cells contribute to nerve mediated contractions of rabbit urethral smooth muscle.
• Rho-associated kinase plays a role in rabbit urethral smooth muscle contraction, but not via enhanced myosin light chain phosphorylation.
• Ionic currents in intimal cultured synoviocytes from the rabbit.
• The PI-PLC inhibitor U-73122 is a potent inhibitor of the SERCA pump in smooth muscle.
• Novel excitatory effects of adenosine triphosphate on contractile and pacemaker activity in rabbit urethral smooth muscle.
• Voltage-dependent Ca2+ currents contribute to spontaneous Ca2+ waves in rabbit corpus cavernosum myocytes.
• Spontaneous Ca2+ waves in rabbit corpus cavernosum: modulation by nitric oxide and cGMP.
• Role of mitochondria in modulation of spontaneous Ca2+ waves in freshly dispersed interstitial cells of Cajal from the rabbit urethra.
• Organization and function of ICC in the urinary tract.
• Ca2+ signalling in urethral interstitial cells of Cajal.
• Pharmacological and molecular evidence for the involvement of Kv4.3 in ultra-fast activating K+ currents in murine portal vein myocytes.
• Contribution of reverse Na+-Ca2+ exchange to spontaneous activity in interstitial cells of Cajal in the rabbit urethra.
• Activation of the cGMP/PKG pathway inhibits electrical activity in rabbit urethral interstitial cells of Cajal by reducing the spatial spread of Ca2+ waves.
• Origin of spontaneous rhythmicity in smooth muscle.
• Interstitial cells of Cajal in the urethra.
• Pacemaker activity in urethral interstitial cells is not dependent on capacitative calcium entry.
• Calcium oscillations in interstitial cells of the rabbit urethra.
• Regulation of Kv4.3 currents by Ca2+/calmodulin-dependent protein kinase II.
• Modulation of spontaneous Ca2+-activated Cl- currents in the rabbit corpus cavernosum by the nitric oxide-cGMP pathway.
• Activation of Ca2+-activated Cl- current by depolarizing steps in rabbit urethral interstitial cells.
• Molecular variants of KCNQ channels expressed in murine portal vein myocytes: a role in delayed rectifier current.
• TRPC4 currents have properties similar to the pacemaker current in interstitial cells of Cajal.
• Microarray comparison of normal and W/Wv mice in the gastric fundus indicates a supersensitive phenotype.
• Regulation of nerve-evoked contractions of rabbit vas deferens by acetylcholine.
• The role of Ca(2+) influx in spontaneous Ca(2+) wave propagation in interstitial cells of Cajal from the rabbit urethra.
• Effects of the novel BK (KCa 1.1) channel opener GoSlo-SR-5-130 are dependent on the presence of BKβ subunits.
• Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: involvement of the S4/S5 linker and the S6 segment.
• Pharmacological characterization of TMEM16A currents.
• Store‐operated Ca2+ influx in native vascular smooth muscle cells relies on interactions between PKCδ, PIP2 and TRPC1 channels
• Ca2+ signalling in mouse urethral smooth muscle in situ: role of Ca2+ stores and Ca2+ influx mechanisms
• A seminal study on the mechanisms underlying spontaneous activity of the seminal vesicles?
• Ca2+‐activated Cl− channels (TMEM16A) underlie spontaneous electrical activity in isolated mouse corpus cavernosum smooth muscle cells
• Modulation of fast sodium current in airway smooth muscle cells by exchange protein directly activated by cAMP
• Evidence of an excitatory purinergic innervation in mouse corpus cavernosum smooth muscle.
• Characterization of norepinephrine-evoked inward currents in interstitial cells isolated from the rabbit urethra.
• TREK-1 regulation by nitric oxide and cGMP-dependent protein kinase. An essential role in smooth muscle inhibitory neurotransmission.
• Spontaneous Ca2+ activated Cl- currents in isolated urethral smooth muscle cells.
• Role of IP(3) in modulation of spontaneous activity in pacemaker cells of rabbit urethra.
• Specialised pacemaking cells in the rabbit urethra.
• Specialised pacemaking cells in the rabbit urethra.
• Role of voltage-gated Ca2+ channels and Ano1 Ca2+-activated Cl− channels in M2 muscarinic receptor-dependent contractions of murine airway smooth muscle
• KV7 channels modulate tension and calcium signalling in mouse corpus cavernosum