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Eftychia Lekka

Senior Investigator (Biomedical and clinical sciences)

Athens, Greece

Achievements

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Publications

  • Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis
  • Topiramate protects apoE-deficient mice from kidney damage without affecting plasma lipids
  • Drug repurposing of Pirlindole for Multiple Sclerosis
  • Association of Microbiome Organisms to Regulatory T Cell function in Cancer and Inflammation
  • Literature analysis for systematic drug repurposing: a case study from Biovista
  • NK Cell Adoptive Transfer Combined with Ontak-Mediated Regulatory T Cell Elimination Induces Effective Adaptive Antitumor Immune Responses
  • Abstract P2-20-03: Combination Immunotherapy for Breast Cancer Patients: Safety and Immunologic Data from a Phase II Trial Administering a HER2/neu-Derived Peptide vaccine (AE37+GM-CSF) Sequentially or Concurrently with Trastuzumab in the Adjuvant Setting
  • Identification and characterization of a HER-2/neu epitope as a potential target for cancer immunotherapy.
  • Peptide vaccination breaks tolerance to HER-2/neu by generating vaccine-specific FasL(+) CD4(+) T cells: first evidence for intratumor apoptotic regulatory T cells.
  • Identification of a novel immunogenic HLA-A*0201-binding epitope of HER-2/neu with potent antitumor properties.
  • Building an Adverse Outcome Pathway network for COVID-19
  • Why adverse outcome pathways need to be FAIR
  • Methods2AOP: An International Collaboration Advancing AOP Key Event Descriptions
  • GABAA receptor-mediated seizure liabilities: a mixed-methods screening approach
  • IND02-05 The NeuroDeRisk toolbox: DeRisking chemical structures for neurotoxic adverse outcomes
  • Rupatadine Treatment Is Associated with Atherosclerosis Worsening and Altered T Lymphocyte Recruitment
  • Association of microbiome organisms to Regulatory T Cell function in cancer and inflammation.

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Co-workers & collaborators

  • Christos Andronis

  • Stephen Edwards

  • Milena Mennecozzi

  • Xiaoqing Chang

  • William Bisson

  • Stephen Ferguson

Eftychia Lekka's public data