Edward Taylor

Publications

• Rational design of a cyclohexanone dehydrogenase for enhanced α, β-desaturation and substrate specificity
• Defining the molecular structure of teixobactin analogues and understanding their role in antibacterial activities
• The copper active site of CBM33 polysaccharide oxygenases
• Structure and kinetic investigation of Streptococcus pyogenes family GH38 alpha-mannosidase
• Structure and activity of the Streptococcus pyogenes family GH1 6-phospho \ensuremathβ-glycosidase, Spy1599
• Haploinsufficiency of the NOTCH1 receptor as a cause of Adams-Oliver Syndrome with variable cardiac anomalies
• Structural insight into the ligand specificity of a thermostable family 51 arabinofuranosidase, Araf 51, from Clostridium thermocellum
• Probing the mechanism of ligand recognition in family 29 carbohydrate-binding modules
• Crystal structure of levansucrase from the Gram-negative bacterium Gluconacetobacter diazotrophicus
• "Syntheses of potent teixobactin analogues against methicillin-resistant Staphylococcus aureus (MRSA) through the replacement of L-allo-enduracididine with its isosteres"
• Efficient total syntheses and biological activities of two teixobactin analogues
• Structure of a carbohydrate esterase from Bacillus anthracis
• Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity
• Crystal structures of Clostridium thermocellum xyloglucanase, XGH74A, reveal the structural basis for xyloglucan recognition and degradation
• Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a \ensuremathβ-N-acetylglucosaminidase and not a hyaluronidase
• Chitinase inhibition by chitobiose and chitotriose thiazolines
• Structures of two truncated phage-tail hyaluronate lyases from Streptococcus pyogenes serotype M1
• Cloning, purification and characterization of the 6-phospho-3-hexulose isomerase YckF from Bacillus subtilis
• The mechanisms by which family 10 glycoside hydrolases bind decorated substrates
• A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of \ensuremathβ-N-acetylglucosaminidases
• Crystal structures of a family 8 polysaccharide lyase reveal open and highly occluded substrate-binding cleft conformations
• The X-ray crystal structure of an Arthrobacter protophormiae endo-beta-N-acetylglucosaminidase reveals a (beta/alpha)(8) catalytic domain, two ancillary domains and active site residues key for transglycosylation activity
• How family 26 glycoside hydrolases orchestrate catalysis on different polysaccharides: structure and activity of a clostridium thermocellum lichenase, CtLic26A
• The structural characterisation of a prophage encoded extracellular DNase from Streptococcus pyogenes
• The structure of a family GH25 lysozyme from Aspergillus fumigatus
• The crystal structure of a family GH25 lysozyme from Aspergillus fumigatus implies a neighboring-group catalytic mechanism with retention of anomeric configuration
• Tailored catalysts for plant cell-wall degradation: Redesigning the exo/endo preference of Cellvibrio japonicus arabinanase 43A
• The use of forced protein evolution to investigate and improve stability of family 10 xylanases: the production of Ca2+-independent stable xylanases
• The gene encoding the ribulose monophosphate pathway enzyme, 3-hexulose-6-phosphate synthase, from Aminomonas aminovorus C2A1 is adjacent to coding sequences that exhibit similarity to histidine biosynthesis enzymes
• Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise
• Structure and activity of two metal ion-dependent acetylxylan esterases involved in plant cell wall degradation reveals a close similarity to peptidoglycan deacetylases
• Structural dissection and high-throughput screening of mannosylglycerate synthase
• Structure of a group A streptococcal phage-encoded virulence factor reveals a catalytically active triple-stranded beta-helix
• Cellvibrio japonicus alpha-L-arabinanase 43A has a novel five-blade beta-propeller fold
• Crystallization and preliminary X-ray diffraction analysis of levansucrase (LsdA) from Gluconacetobacter diazotrophicus SRT4
• Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding
• Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo
• The C-Type Lysozyme from the upper Gastrointestinal Tract of Opisthocomus hoatzin, the Stinkbird.
• Cysteines and Disulfide-Bridged Macrocyclic Mimics of Teixobactin Analogues and Their Antibacterial Activity Evaluation against Methicillin-Resistant Staphylococcus Aureus (MRSA).
• Exploring metabolic adaptation of Streptococcus pneumoniae to antibiotics.
• Fungal GH25 muramidases: New family members with applications in animal nutrition and a crystal structure at 0.78Å resolution.
• De Novo Resistance to Arg 10 -Teixobactin Occurs Slowly and Is Costly