Direk Limmathurotsakul

Publications

  • Impact of a multimodal hand hygiene improvement intervention in a 1000-bed hospital in NE Thailand: a stepped wedge clustered randomized controlled trial
  • Evaluation of consensus method for the culture of Burkholderia pseudomallei in soil samples from Laos [version 1; referees: 1 approved, 1 approved with reservations]
  • Global Burden and Challenges of Melioidosis
  • Surveillance and Epidemiology of Drug Resistant Infections Consortium (SEDRIC): Supporting the transition from strategy to action [version 1; referees: awaiting peer review]
  • Management and outcomes of severe dengue patients presenting with sepsis in a tropical country
  • Feasibility and initial outcomes of a multifaceted prevention programme of melioidosis in diabetic patients in Ubon Ratchathani, northeast Thailand
  • Clinical epidemiology and outcomes of community acquired infection and sepsis among hospitalized patients in a resource limited setting in Northeast Thailand: A prospective observational study (Ubon-sepsis)
  • Misidentification of Burkholderia pseudomallei as Acinetobacter species in northern Thailand
  • Thrombocytopenia Impairs Host Defense Against Burkholderia pseudomallei (Melioidosis)
  • Genome sequencing defines phylogeny and spread of methicillin-resistant Staphylococcus aureus in a high transmission setting
  • Impact of routine bedside infectious diseases consultation on clinical management and outcome of Staphylococcus aureus bacteraemia in adults
  • Comprehensive analysis of clinical Burkholderia pseudomallei isolates demonstrates conservation of unique lipid A structure and TLR4-dependent innate immune activation
  • Clinical and molecular epidemiology of Staphylococcus argenteus infections in Thailand
  • Extended Loop Region of Hcp1 is Critical for the Assembly and Function of Type VI Secretion System in Burkholderia pseudomallei
  • Antibiotic therapy for Staphylococcus aurcus colonised vascular catheter tips and the occurrence of bacteraemia-implications for hospital policy
  • Cost-effectiveness analysis of parenteral antimicrobials for acute melioidosis in Thailand
  • Consensus on the Development of Vaccines against Naturally Acquired Melioidosis.
  • How to Determine the Accuracy of an Alternative Diagnostic Test when It Is Actually Better than the Reference Tests: A Re-Evaluation of Diagnostic Tests for Scrub Typhus Using Bayesian LCMs
  • Antimicrobial Disk Susceptibility Testing of Leptospira spp. Using Leptospira Vanaporn Wuthiekanun Agar
  • Cost-effectiveness of hand hygiene promotion for MRSA blood stream infection in ICU settings
  • Evaluation of Polysaccharide-Based Latex Agglutination Assays for the Rapid Detection of Antibodies to Burkholderia pseudomallei
  • Sensitivity and specificity of a lateral flow immunoassay (LFI) in serum samples for diagnosis of melioidosis
  • Utility of SOFA score, management and outcomes of sepsis in Southeast Asia: a multinational multicenter prospective observational study
  • Leapfrogging laboratories: the promise and pitfalls of high-tech solutions for antimicrobial resistance surveillance in low-income settings
  • Clinical Epidemiology of 7,126 Melioidosis Patients in Thailand and the Implications for a National Notifiable Diseases Surveillance System
  • Effectiveness of a multifaceted prevention programme for melioidosis in diabetics (PREMEL): a stepped-wedge cluster-randomised controlled trial
  • Exonic sequencing identifies TLR1 genetic variation associated with mortality in Thais with melioidosis
  • Pan-drug-resistant and biofilm-producing strain of Burkholderia pseudomallei: first report of melioidosis from a diabetic patient in Yogyakarta, Indonesia [Letter]
  • ‘Antibiotic footprint’ as a communication tool to aid reduction of antibiotic consumption
  • Survival of Burkholderia pseudomallei and Pathogenic Leptospira in Cola, Beer, Energy Drinks, and Sports Drinks.
  • In vitro passage alters virulence, immune activation and proteomic profiles of Burkholderia pseudomallei.
  • Case-Control Study of Use of Personal Protective Measures and Risk for Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Thailand.
  • Lactoferrin is a dynamic protein in human melioidosis and is a TLR4-dependent driver of TNF-α release in Burkholderia thailandensis infection in vitro.
  • A Comparison Between 12 Versus 20 Weeks of Trimethoprim-Sulfamethoxazole as Oral Eradication Treatment for Melioidosis (12vs20): An Open-label, Pragmatic, Multicenter, Non-inferiority, Randomized Controlled Trial.
  • Serum From Melioidosis Survivors Diminished Intracellular Burkholderia pseudomallei Growth in Macrophages: A Brief Research Report.
  • sTREM-1 predicts mortality in hospitalized patients with infection in a tropical, middle-income country.
  • Antimicrobial Resistance Surveillance in Low- and Middle-Income Countries: Progress and Challenges in Eight South Asian and Southeast Asian Countries.
  • Genetic variation associated with infection and the environment in the accidental pathogen Burkholderia pseudomallei.
  • Human Immune Responses to Melioidosis and Cross-Reactivity to Low-Virulence Burkholderia Species, Thailand1.
  • Multiple phylogenetically-diverse, differentially-virulent Burkholderia pseudomallei isolated from a single soil sample collected in Thailand
  • ‘Antibiotic footprint’ as a communication tool to aid reduction of antibiotic consumption—authors’ response
  • Barriers and Recommended Interventions to Prevent Melioidosis in Northeast Thailand: A Focus Group Study Using the Behaviour Change Wheel
  • Epidemiology and burden of multidrug-resistant bacterial infection in a developing country
  • Soil Nutrient Depletion Is Associated with the Presence of Burkholderia pseudomallei
  • Improved characterisation of MRSA transmission using within-host bacterial sequence diversity
  • Utility of qSOFA and modified SOFA in severe malaria presenting as sepsis
  • Early management of sepsis in medical patients in rural Thailand: a single-center prospective observational study
  • The utility of an AMR dictionary as an educational tool to improve public understanding of antimicrobial resistance [version 1; peer review: 1 approved]
  • Effectiveness of a multifaceted prevention programme for melioidosis in diabetics (PREMEL): A stepped-wedge cluster-randomised controlled trial
  • “AMR Dialogues”: a public engagement initiative to shape policies and solutions on antimicrobial resistance (AMR) in Thailand [version 2; peer review: 2 approved]
  • NLRC4 and TLR5 each contribute to host defense in respiratory melioidosis
  • Impact of infectious diseases consultation on the management of S. aureus bacteraemia in children
  • Melioidosis in Africa: should we be looking more closely?(vol 10, pg 273, 2015)
  • Subpopulations of Staphylococcus aureus clonal complex 121 are associated with distinct clinical entities
  • Using a web-based application to define the accuracy of diagnostic tests when the gold standard is imperfect
  • Impaired TLR5 functionality is associated with survival in melioidosis
  • A matched case-control study identifies activities of daily living associated with acquisition of melioidosis in northeast Thailand
  • Epidemiology, microbiology and mortality associated with community-acquired bacteremia in northeast Thailand: a multicenter surveillance study
  • Evaluation of a latex agglutination assay for the identification of Burkholderia pseudomallei and Burkholderia mallei
  • Molecular confirmation of co-infection by pathogenic Leptospira spp. and Orientia tsutsugamushi in patients with acute febrile illness in Thailand
  • Common TLR1 genetic variation is not associated with death from melioidosis, a common cause of sepsis in rural Thailand
  • Impact of infectious diseases consultation on the management of Staphylococcus aureus bacteraemia in children
  • Trimethoprim/sulfamethoxazole resistance in clinical isolates of Burkholderia pseudomallei from Thailand.
  • Public awareness of melioidosis in Thailand and potential use of video clips as educational tools.
  • Mortality Attributable to Seasonal Influenza A and B Infections in Thailand, 2005--2009: A Longitudinal Study
  • Paragonimiasis as an Important Alternative Misdiagnosed Disease for Suspected Acid-fast Bacilli Sputum Smear-Negative Tuberculosis Response
  • Systematic review and consensus guidelines for environmental sampling of Burkholderia pseudomallei
  • Estimating the true accuracy of diagnostic tests for dengue infection using bayesian latent class models
  • Microevolution of Burkholderia pseudomallei during an acute infection
  • Burkholderia pseudomallei in Water Supplies, Southern Thailand
  • Increasing incidence of hospital-acquired and healthcare-associated bacteremia in northeast Thailand: a multicenter surveillance study
  • Failure of Burkholderia pseudomallei to Grow in an Automated Blood Culture System
  • Development of a prototype lateral flow immunoassay (LFI) for the rapid diagnosis of melioidosis
  • Maintenance of Leptospira Species in Leptospira Vanaporn Wuthiekanun Agar
  • Activities of daily living associated with acquisition of melioidosis in northeast Thailand: a matched case-control study
  • Host responses to melioidosis and tuberculosis are both dominated by interferon-mediated signaling
  • A qualitative exploration into infection control practices and obstacles to improvements amongst health care workers at a regional hospital
  • Long-term survival after intensive care unit discharge in Thailand: a retrospective study
  • Rapid isolation and susceptibility testing of Leptospira spp. using a new solid medium, LVW agar
  • The epidemiology of pediatric bone and joint infections in Cambodia, 2007--11
  • Monoclonal antibody-based immunofluorescence microscopy for the rapid identification of Burkholderia pseudomallei in clinical specimens
  • Correction: Melioidosis Vaccines: A Systematic Review and Appraisal of the Potential to Exploit Biodefense Vaccines for Public Health Purposes
  • The value of intermittent point-prevalence surveys of healthcare-associated infections for evaluating infection control interventions at Angkor Hospital for Children, Siem Reap, Cambodia
  • Leptospira species in floodwater during the 2011 floods in the Bangkok Metropolitan Region, Thailand
  • Clinical definitions of melioidosis
  • Correction: Epidemiology, Microbiology and Mortality Associated with Community-Acquired Bacteremia in Northeast Thailand: A Multicenter Surveillance Study
  • Prevalence of melioidosis in patients with suspected pulmonary tuberculosis and sputum smear negative for acid-fast bacilli in northeast Thailand
  • Rapid detection of Burkholderia pseudomallei in blood cultures using a monoclonal antibody-based immunofluorescent assay
  • Melioidosis caused by Burkholderia pseudomallei in drinking water, Thailand, 2012
  • Determinants of mortality in a combined cohort of 501 patients with HIV-associated cryptococcal meningitis: implications for improving outcomes
  • The role of NOD2 in murine and human melioidosis
  • Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial
  • Role of Burkholderia pseudomallei biofilm formation and lipopolysaccharide in relapse of melioidosis
  • Zero tolerance for healthcare-associated MRSA bacteraemia: is it realistic?
  • Environmental presence of Burkholderia pseudomallei in rice fields as determined by direct PCR from soil samples
  • Fatal melioidosis in goats in Bangkok, Thailand
  • Melioidosis Diagnostic Workshop, 2013
  • Maintenance of Leptospira spp. in LVW agar
  • Melioidosis in Africa: should we be looking more closely?
  • New Insights from the 7th World Melioidosis Congress 2013
  • Burkholderia pseudomallei is spatially distributed in soil in northeast Thailand
  • Patterns of organ involvement in recurrent melioidosis
  • Gamma interferon supplementation for melioidosis
  • Defining the true sensitivity of culture for the diagnosis of melioidosis using Bayesian latent class models
  • Enzyme-linked immunosorbent assay for the diagnosis of melioidosis: better than we thought
  • Within-host evolution of Burkholderia pseudomallei in four cases of acute melioidosis
  • i 1 August News iii In the Literature v Crossing Borders: One World, Global Health
  • Glyburide is anti-inflammatory and associated with reduced mortality in melioidosis
  • Fool's gold: Why imperfect reference tests are undermining the evaluation of novel diagnostics: a reevaluation of 5 diagnostic tests for leptospirosis
  • Burkholderia pseudomallei is genetically diverse in agricultural land in Northeast Thailand
  • Effect of colony morphology variation of Burkholderia pseudomallei on intracellular survival and resistance to antimicrobial environments in human macrophages in vitro
  • Accuracy of a commercial IgM ELISA for the diagnosis of human leptospirosis in Thailand
  • Prospective observational study of the frequency and features of intra-abdominal abscesses in patients with melioidosis in northeast Thailand
  • Toll-Like Receptor Pathway Gene Variants And Susceptibility To Melioidosis
  • Proteomic analysis of colony morphology variants of Burkholderia pseudomallei defines a role for the arginine deiminase system in bacterial survival
  • Molecular detection and speciation of pathogenic Leptospira spp. in blood from patients with culture-negative leptospirosis
  • Increasing incidence of human melioidosis in Northeast Thailand
  • Independent association between rate of clearance of infection and clinical outcome of HIV-associated cryptococcal meningitis: analysis of a combined cohort of 262 patients
  • Melioidosis in animals, Thailand, 2006--2010
  • Repeat blood culture positive for B. pseudomallei indicates an increased risk of death from melioidosis
  • Pathogenicity of high-dose enteral inoculation of Burkholderia pseudomallei to mice
  • Animal melioidosis in Thailand
  • Defining the true accuracy of diagnostic tests when the gold standard is imperfect using web-based application
  • Workshop on treatment of and postexposure prophylaxis for Burkholderia pseudomallei and B. mallei infection, 2010
  • Development and validation of Burkholderia pseudomallei-specific real-time PCR assays for clinical, environmental or forensic detection applications
  • Melioidosis: a clinical overview
  • Diagnostic accuracy of real-time PCR assays targeting 16S rRNA and lipL32 genes for human leptospirosis in Thailand: a case-control study
  • Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in Burkholderia pseudomallei
  • Phenotypic and functional characterization of human memory T cell responses to Burkholderia pseudomallei
  • Human immune responses to Burkholderia pseudomallei characterized by protein microarray analysis
  • Toll-like receptor 4 region genetic variants are associated with susceptibility to melioidosis
  • Survey of antimicrobial resistance in clinical B. pseudomallei isolates over two decades in northeast Thailand
  • Melioidosis vaccines: a systematic review and appraisal of the potential to exploit biodefense vaccines for public health purposes
  • Development of ceftazidime resistance in an acute Burkholderia pseudomallei infection
  • Long-term outcome of Q fever endocarditis
  • Highly sensitive direct detection and quantification of Burkholderia pseudomallei bacteria in environmental soil samples by using real-time PCR
  • Feasibility of modified surviving sepsis campaign guidelines in a resource-restricted setting based on a cohort study of severe S. aureus sepsis
  • Effectiveness of a Simplified Method for Isolation of Burkholderia pseudomallei from Soil
  • Improved culture-based detection and quantification of Burkholderia pseudomallei from soil
  • Rate of clearance of infection is independently associated with clinical outcome in HIV-associated cryptococcal meningitis: analysis of a combined cohort of 262 patients
  • Accuracy of loop-mediated isothermal amplification for diagnosis of human leptospirosis in Thailand
  • Excess length of stay due to hospital-associated infections in Thailand: 8 years retrospective data
  • A retrospective study to define the incidence and associated mortality of hospital-acquired bacteraemia at a regional hospital in northeast Thailand
  • Correction: Diagnostic Accuracy of Real-Time PCR Assays Targeting 16S rRNA and lipl32 Genes for Human Leptospirosis in Thailand: A Case-Control Study
  • Lack of correlation of Burkholderia pseudomallei quantities in blood, urine, sputum and pus
  • Epidemiology, microbiology and mortality of community-acquired bacteremia in northeast Thailand: a multicenter population-based study
  • Correction: Feasibility of Modified Surviving Sepsis Campaign Guidelines in a Resource-Restricted Setting Based on a Cohort Study of Severe S. Aureus Sepsis.
  • Pediatric Suppurative Parotitis in Cambodia 2007-2011
  • Identification of differentially expressed proteins from Burkholderia pseudomallei isolated during primary and relapsing melioidosis
  • Europe PMC Funders Group
  • Burkholderia pseudomallei genome plasticity associated with genomic island variation
  • A randomized controlled trial of granulocyte colony-stimulating factor for the treatment of severe sepsis due to melioidosis in Thailand
  • Trimethoprim/sulfamethoxazole resistance in clinical isolates of Burkholderia pseudomallei
  • MICE: An open-access tool for accuracy estimates of diagnostic tests in absence of a gold standard
  • ARTICLES AND COMMENTARIES-A Randomized Controlled Trial of Granulocyte Colony-Stimulating Factor for the Treatment of Severe Sepsis Due to Melioidosis in Thailand
  • Variable presentation of neurological melioidosis in Northeast Thailand
  • Prospective clinical evaluation of the accuracy of 16S rRNA real-time PCR assay for the diagnosis of melioidosis
  • turning green with shock
  • Biological relevance of colony morphology and phenotypic switching by Burkholderia pseudomallei
  • Open-label randomized trial of oral trimethoprim-sulfamethoxazole, doxycycline, and chloramphenicol compared with trimethoprim-sulfamethoxazole and doxycycline for maintenance therapy of melioidosis
  • Two randomized controlled trials of ceftazidime alone versus ceftazidime in combination with trimethoprim-sulfamethoxazole for the treatment of severe melioidosis
  • Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria
  • Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis)
  • Evaluating Burkholderia pseudomallei Bip proteins as vaccines and Bip antibodies as detection agents
  • Role and significance of quantitative urine cultures in diagnosis of melioidosis
  • Consensus guidelines for dosing of amoxicillin-clavulanate in melioidosis
  • Efforts to Enhance Detection of Burkholderia pseudomallei Among Young Children with Severe Pneumonia
  • Melioidosis, 2011-Thailand: drinking water source
  • Rapid immunofluorescence microscopy for diagnosis of melioidosis
  • Risk factors for recurrent melioidosis in northeast Thailand
  • Genetic diversity and microevolution of Burkholderia pseudomallei in the environment
  • An addition to the effect of treating co-infections on HIV-1 viral load
  • Staphylococcus aureus bacteraemia in a tropical setting: patient outcome and impact of antibiotic resistance
  • Prospective evaluation of a rapid immunochromogenic cassette test for the diagnosis of melioidosis in northeast Thailand
  • Accuracy of enzyme-linked immunosorbent assay using crude and purified antigens for serodiagnosis of melioidosis
  • Relationship of cerebrospinal fluid pressure, fungal burden and outcome in patients with cryptococcal meningitis undergoing serial lumbar punctures
  • High-throughput mRNA profiling characterizes the expression of inflammatory molecules in sepsis caused by Burkholderia pseudomallei
  • Strategies to reduce mortality from bacterial sepsis in adults in developing countries
  • Optimization of culture of Leptospira from humans with leptospirosis
  • Antibodies from patients with melioidosis recognize Burkholderia mallei but not Burkholderia thailandensis antigens in the indirect hemagglutination assay
  • Quantitation of B. pseudomallei in clinical samples
  • Simultaneous infection with more than one strain of Burkholderia pseudomallei is uncommon in human melioidosis
  • Loop-mediated isothermal amplification method targeting the TTS1 gene cluster for detection of Burkholderia pseudomallei and diagnosis of melioidosis
  • A simple scoring system to differentiate between relapse and re-infection in patients with recurrent melioidosis
  • Invasive Erysipelothrix rhusiopathiae infection in northeast Thailand.
  • Intensity of exposure and incidence of melioidosis in Thai children
  • Rheumatological manifestations in patients with melioidosis.
  • Determinants of recurrent melioidosis
  • Toll-Like Receptor Pathway Gene Variants And Susceptibility To Melioidosis
  • Automating the Generation of Antimicrobial Resistance Surveillance Reports: Proof-of-Concept Study Involving Seven Hospitals in Seven Countries.

Usage metrics

Co-workers & collaborators

Viriya Hantrakun

Viriya Hantrakun

Direk Limmathurotsakul's public data