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Dilraj Lama

Publications

  • Differential Binding Affinities of Anti-Apoptotic MCL-1 and A1 Proteins for the Pro-Apoptotic BH3 Peptides: Understanding the Molecular Basis using MD Simulations.
  • Stapled-peptides targeting the protein-binding interface of eukaryotic Translation Initiation Factor 4E (eIF4E) protein
  • Rational optimization of conformational effects induced by hydrocarbon staples in peptides and their binding interfaces.
  • Electrospray ionization of native membrane proteins proceeds via a charge equilibration step.
  • A "spindle and thread" mechanism unblocks p53 translation by modulating N-terminal disorder.
  • Therapeutic anti-cancer activity of antibodies targeting sulfhydryl bond constrained epitopes on unglycosylated RON receptor tyrosine kinase.
  • Development of a novel peptide aptamer that interacts with the eIF4E capped-mRNA binding site using peptide epitope linker evolution (PELE).
  • Conformational ordering of intrinsically disordered peptides for targeting translation initiation.
  • Deciphering the mechanistic effects of eIF4E phosphorylation on mRNA-cap recognition.
  • c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression.
  • R248Q mutation--Beyond p53-DNA binding.
  • USP15 regulates SMURF2 kinetics through C-lobe mediated deubiquitination.
  • Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
  • Homologous Lympho-Epithelial Kazal-type Inhibitor Domains Delay Blood Coagulation by Inhibiting Factor X and XI with Differential Specificity.
  • Water-Bridge Mediates Recognition of mRNA Cap in eIF4E.
  • Gating by tryptophan 73 exposes a cryptic pocket at the protein-binding interface of the oncogenic eIF4E protein.
  • Evidence of a conserved intrinsically disordered region in the C-terminus of the stringent response protein Rel from mycobacteria.
  • Behavior of solvent-exposed hydrophobic groove in the anti-apoptotic Bcl-XL protein: clues for its ability to bind diverse BH3 ligands from MD simulations.
  • Molecular dynamics simulations of pro-apoptotic BH3 peptide helices in aqueous medium: relationship between helix stability and their binding affinities to the anti-apoptotic protein Bcl-X(L).
  • Identification of core structural residues in the sequentially diverse and structurally homologous Bcl-2 family of proteins.
  • Anti-apoptotic Bcl-XL protein in complex with BH3 peptides of pro-apoptotic Bak, Bad, and Bim proteins: comparative molecular dynamics simulations.
  • Stapled peptidomimetic therapeutics
  • TRAF4 inhibits bladder cancer progression by promoting BMP/SMAD signalling.
  • Plasticity of BH3 domain-binding hydrophobic grooves in the anti-apoptotic proteins Mcl-1 and A1
  • Phosphorylation regulates auto-inhibition of kinesin KIF3A
  • Inhibition of p53-MDM2 protein interaction reduces tumor growth in mouse melanoma model

Dilraj Lama's public data