Deborah Baines

Publications

• Glucose Transport and Homeostasis in Lung Epithelia
• Glucose homeostasis across human airway epithelial cell monolayers: Role of diffusion, transport and metabolism
• Dapagliflozin-lowered blood glucose reduces respiratory Pseudomonas aeruginosa infection in diabetic mice
• AMP-activated protein kinase (AMPK)-dependent and -independent pathways regulate hypoxic inhibition of transepithelial Na+ transport across human airway epithelial cells
• Elevated Paracellular Glucose Flux across Cystic Fibrosis Airway Epithelial Monolayers Is an Important Factor for Pseudomonas aeruginosa Growth
• Estrogen and progesterone regulate α, β, and γENaC subunit mRNA levels in female rat kidney
• The epithelial sodium channel mediates the directionality of galvanotaxis in human keratinocytes
• Hyperglycaemia and pulmonary infection
• PPARγ agonists inhibit vasopressin-mediated anion transport in the MDCK-C7 cell line
• AICAR activates AMPK and alters PIP 2 association with the epithelial sodium channel ENaC to inhibit Na+ transport in H441 lung epithelial cells
• Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose
• The hormonal control of uterine luminal fluid secretion and absorption
• KCNQ-encoded channels regulate Na+ transport across H441 lung epithelial cells
• Apical and basolateral localisation of GLUT2 transporters in human lung epithelial cells
• TGF-β activates ERK5 in human renal epithelial cells
• New insights into the glucose oxidase stick test for cerebrospinal fluid rhinorrhoea
• Fructose transport-deficient Staphylococcus aureus reveals important role of epithelial glucose transporters in limiting sugar-driven bacterial growth in airway surface liquid
• Vasopressin regulates the phosphorylation state of AMP-activated protein kinase (AMPK) in MDCK-C7 cells
• Lipopolysaccharide modifies amiloride-sensitive Na+ transport processes across human airway cells: Role of mitogen-activated protein kinases ERK 1/2 and 5
• Effective glucose metabolism maintains low intracellular glucose in airway epithelial cells after exposure to hyperglycemia
• AICAR decreases the activity of two distinct amiloride-sensitive Na +-permeable channels in H441 human lung epithelial cell monolayers
• Hyperglycemia and cystic fibrosis alter respiratory fluid glucose concentrations estimated by breath condensate analysis
• Sweet talk: Insights into the nature and importance of glucose transport in lung epithelium
• Metformin attenuates the effect of Staphylococcus aureus on airway tight junctions by increasing PKCζ-mediated phosphorylation of occludin
• Increased airway glucose increases airway bacterial load in hyperglycaemia
• The phosphorylation of endogenous Nedd4-2 in Na+ - Absorbing human airway epithelial cells
• Kinases as targets for ENaC regulation
• Cleavage of endogenous γENaC and elevated abundance of αENaC are associated with increased Na + transport in response to apical fluid volume expansion in human H441 airway epithelial cells
• Valproic acid protects against haemorrhagic shock-induced signalling changes via PPARγ activation in an in vitro model
• Erk5 is a mediator to TGFβ1-induced loss of phenotype and function in human podocytes
• Oxygen-evoked changes in transcriptional activity of the 5′-flanking region of the human amiloride-sensitive sodium channel (αENaC) gene: Role of nuclear factor κB
• Role played by Disabled-2 in albumin induced MAP Kinase signalling
• Glucose in bronchial aspirates increases the risk of respiratory MRSA in intubated patients
• The gasotransmitter hydrogen sulphide decreases Na + transport across pulmonary epithelial cells
• Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H + secretion
• Proinflammatory mediators disrupt glucose homeostasis in airway surface liquid
• Airway glucose concentrations and effect on growth of respiratory pathogens in cystic fibrosis
• Airway Glucose Homeostasis: A New Target in the Prevention and Treatment of Pulmonary Infection
• Interaction between extracellular matrix molecules and microbial pathogens: Evidence for the missing link in autoimmunity with rheumatoid arthritis as a disease model
• A novel fluorescent sensor protein for detecting changes in airway surface liquid glucose concentration
• Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung
• A nasty case of the vapours – e-cigarettes friend or foe?
• Metformin prevents the effects of Pseudomonas aeruginosa on airway epithelial tight junctions and restricts hyperglycaemia-induced bacterial growth
• BMI-1 extends proliferative potential of human bronchial epithelial cells while retaining their mucociliary differentiation capacity
• Forskolin-induced cell shrinkage and apical translocation of functional enhanced green fluorescent protein-human αENaC in H441 lung epithelial cell monolayers
• Phenformin and 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) activation of AMP-activated protein kinase inhibits transepithelial Na+ transport across H441 lung cells
• Hyperglycaemia is associated with poor outcomes in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonary disease
• Passaging Primary Human Bronchial Epithelia Reduces CFTR-Mediated Fluid Transport and Alters mRNA Expression
• Pharmacological activators of AMP-activated protein kinase have different effects on Na + transport processes across human lung epithelial cells
• Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a TRPP2 (polycystin-2)-dependent manner
• Activation of apical P2U purine receptors permits inhibition of adrenaline-evoked cyclic AMP accumulation in cultured equine sweat gland epithelial cells
• Immunohistochemical detection of sodium channel in human tissue and cell lines
• P2Y2 receptor-mediated inhibition of ion transport in distal lung epithelial cells
• Oxygen-evoked Na+ transport in rat fetal distal lung epithelial cells
• The influence of mode of delivery, hormonal status and postnatal O2 environment on epithelial sodium channel (ENaC) expression in perinatal guinea-pig lung
• Inwardly rectifying K+ currents in fetal alveolar type II cells: Regulation by protein kinase A and protein phosphatases
• Effects of sodium butyrate on the expression of sodium channels by neuronal cell lines derived from the rat CNS
• Multiple P2Y receptor subtypes in the apical membranes of polarized epithelial cells
• Alveolar epithelial fluid clearance is mediated by endogenous catecholamines at birth in guinea pigs
• Role of endogenous cortisol in basal liquid clearance from distal air spaces in adult guinea-pigs
• Perinatal PTX-sensitive G-protein expression and regulation of conductive 22Na+ transport in lung apical membrane vesicles
• Fatty acid modulation and sequence identity of fetal guinea pig alveolar type II cell amiloride-sensitive NA + channel
• Salt and water transport across the alveolar epithelium in the developing lung: correlations between function and recent molecular biology advances (Review).
• Culture substrate-specific expression of P2Y2 receptors in distal lung epithelial cells isolated from foetal rats
• Inwardly rectifying K+ currents of alveolar type II cells isolated from fetal guinea-pig lund: Regulation by G protein- and Mg2+-dependent pathways
• Differential regulation of Na+ and Cl- conductances by PTX-sensitive G proteins in fetal lung apical membrane vesicles
• The effects of P(o2) upon transepithelial ion transport in fetal rat distal lung epithelial cells