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Dave Bridges

Assistant Professor (Biochemistry and cell biology not elsewhere classified)

University of Tennessee Health Science Center

My overall career goals have been to understand the molecular networks that lie at the intersection between metabolism and health. I did my undergraduate and doctoral training in Biochemistry at the University of Calgary, in Calgary, Alberta, Canada followed by a fellowship with Dr. Alan Saltiel at the University of Michigan. During that time we used several model systems including yeast, flies and mice to elucidate a variety of novel aspects of metabolic regulation. As a member of the joint UTHSC-Le Bonheur Pediatric Obesity program, my group studies the molecular, cellular and physiological changes associated with obesity. We are particularly interested in the role of the central nutrient responsive protein kinase mTORC1, how it is altered in weight gain and how its activation affects obesity related co-morbidities. With a better understanding of the molecular mechanisms underlying obesity, we hope to better prevent and treat obesity in the future.

Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy.
  • The p11 subunit of annexin II heterotetramer is regulated by basic carboxypeptidase DOI: 10.1021/bi012045y
  • Detection of multiple splice variants of the nuclear protein phosphatase 1 regulator sds22 in rat liver nuclei DOI: 10.1139/o02-155
  • Purification of a plant nucleotide pyrophosphatase as a protein that interferes with nitrate reductase and glutamine synthetase assays DOI: 10.1046/j.1432-1033.2003.03509.x
  • 14-3-3 proteins: a number of functions for a numbered protein.
  • Cyclic nucleotide binding proteins in the Arabidopsis thaliana and Oryza sativa genomes DOI: 10.1186/1471-2105-6-6
  • 14-3-3 proteins: a number of functions for a numbered protein.
  • Identification and characterization of D-AKAP1 as a major adipocyte PKA and PP1 binding protein DOI: 10.1016/j.bbrc.2006.05.138
  • Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5 DOI: 10.1091/mbc.E08-01-0105
  • p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity DOI: 10.1073/pnas.1103638109
  • TC10 is regulated by Caveolin in 3T3-L1 Adipocytes DOI: 10.1371/journal.pone.0042451
  • Rab5 proteins regulate activation and localization of target of rapamycin complex 1 DOI: 10.1074/jbc.M111.334060
  • Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1 DOI: 10.1091/mbc.E11-12-1034
  • Inhibition of AMPK Catabolic Action by GSK3 DOI: 10.1016/j.molcel.2013.03.022
  • Phosphoinositides in insulin action and diabetes.

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Co-workers & collaborators

Peter Mancuso

Associate Professor - Ann Arbor, MI, USA

Peter Mancuso

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