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Daniel Slade

0000-0001-5634-7220

Assistant Professor (Biochemistry and cell biology not elsewhere classified)

Virginia Tech

Dan grew up on the east coast, but his sports devotion still lies with his earliest upbringing in Massachusetts, where he learned to love the Red Sox and Patriots. A meager .240 career batting average as a college baseball player ruled out playing alongside his friends and opponents in the major leagues, so he pursued a career as a biochemist upon entering graduate school. Fast forward several years and add in a healthy dose of microbiology and protein structure function, and the basis for pursuing how bacteria are contributing to cancer was born in The Slade Lab. Dan has surrounded himself with women that are far smarter than him (1 wife, 2 daughters), which keeps him on his toes to say the least. His passion for understanding the role of our microbiome in tumor development has been fueled by a fascination with bacterial virulence factors, and a true desire to make significant findings that will enable future colorectal cancer therapies and vaccines. He is a fan of lab bowling nights, group coffee breaks with pathways drawn on napkins, and extremely difficult cloning projects that have the potential for utter failure or complete euphoria.

Publications

  • Protein Arginine Deiminase 2 Binds Calcium in an Ordered Fashion: Implications for Inhibitor Design DOI: 10.1021/cb500933j
  • Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation DOI: 10.1038/nchembio.1735
  • Pluripotency: citrullination unravels stem cells DOI: 10.1038/nchembio.1504
  • Chemical and biological methods to detect post-translational modifications of arginine DOI: 10.1002/bip.22256
  • A novel role for protein arginine deiminase 4 in pluripotency: the emerging role of citrullinated histone H1 in cellular programming DOI: 10.1002/bies.201400057
  • Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor alpha target gene activation DOI: 10.1073/pnas.1203280109
  • Genetic reporter system for positioning of proteins at the bacterial pole DOI: 10.1128/mBio.00251-11
  • Activation of PAD4 in NET formation DOI: 10.3389/fimmu.2012.00360
  • Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit DOI: 10.1016/j.jmb.2008.03.061
  • Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding DOI: 10.1016/j.molimm.2007.06.359
  • Functional studies of the MACPF domain of human complement protein C8alpha reveal sites for simultaneous binding of C8beta, C8gamma, and C9 DOI: 10.1021/bi0601860
  • Binding of the lipocalin C8gamma to human complement protein C8alpha is mediated by loops located at the entrance to the C8gamma ligand binding site DOI: 10.1016/j.bbapap.2006.07.003
  • Chemical Proteomic Platform To Identify Citrullinated Proteins DOI: 10.1021/acschembio.5b00438
  • Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M DOI: 10.1016/j.ebiom.2016.11.039

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