Christoph Schweingruber

Publications

• Interactions of CstF-64, CstF-77, and symplekin: implications on localisation and function.
• Nonsense-mediated mRNA decay - mechanisms of substrate mRNA recognition and degradation in mammalian cells.
• The host nonsense-mediated mRNA decay pathway restricts Mammalian RNA virus replication.
• Identification of Interactions in the NMD Complex Using Proximity-Dependent Biotinylation (BioID).
• Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants.
• LCM-seq reveals unique transcriptional adaption mechanisms of resistant neurons in spinal muscular atrophy
• A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate.
• Modeling motor neuron resilience in ALS using stem cells
• Modeling Motor Neuron Resilience in ALS Using Stem Cells
• LCM-seq reveals unique transcriptional adaptation mechanisms of resistant neurons and identifies protective pathways in spinal muscular atrophy
• Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis
• The Cell Autonomous and Non-Cell Autonomous Aspects of Neuronal Vulnerability and Resilience in Amyotrophic Lateral Sclerosis
• Single cell RNA sequencing in isogenic FUS and TARDBP mutant ALS lines reveals early mitochondrial dysfunction as a common pathway in motor neurons
• Single cell RNA sequencing in isogenicFUSandTARDBPmutant ALS lines reveals early mitochondrial dysfunction as a common pathway in motor neurons
• Human motor neurons are rare and can be transcriptomically divided into known subtypes
• Challenges of profiling motor neuron transcriptomes from human spinal cord
• Single-cell RNA sequencing across isogenic FUS and TARDBP ALS lines reveals a shared early mitochondrial dysfunction unique to motor neurons.
• Single-cell RNA sequencing across isogenicFUSandTARDBPALS lines reveals a shared early mitochondrial dysfunction unique to motor neurons