Christian Cole

Principle Investigator, Leverhulme Research Centre for Forensic Science (Information and computing sciences)

Dundee, Scotland

Christian Cole is a Principal Investigator at the Leverhulme Research Centre for Forensic Science (LRCFS). His expertise and passion is in Bioinformatics and Data Science gained over his postdoctoral career. At LRCFS Chris will be using his multi-disciplinary computational approaches to challenge existing weaknesses in the analysis and interpretation of several forensic evidence types. Chris's research interest in increasing openness and reproducibility in Forensic Science especially in the application of automated systems and machine learning.

Publications

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. DOI: 10.1016/j.jaci.2013.08.046
Direct sequencing of Arabidopsis thaliana RNA reveals patterns of cleavage and polyadenylation DOI: 10.1038/nsmb.2345
Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma DOI: 10.1038/ng.2444
A Dictyostelium SH2 adaptor protein required for correct DIF-1 signaling and pattern formation DOI: 10.1016/j.ydbio.2011.03.003
Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins DOI: 10.1042/BJ20100024
Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs DOI: 10.1261/rna.1738409
System-wide changes to sumo modifications in response to heat shock DOI: 10.1126/scisignal.2000282
The Jpred 3 secondary structure prediction server. DOI: 10.1093/nar/gkn238
Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs DOI: 10.1021/jm049494r
3-Substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: Mechanism of activation and cytotoxicity in vitro DOI: 10.1016/S0006-2952(03)00452-0
Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: Inhibitors of the angiogenic enzyme thymidine phosphorylase DOI: 10.1021/jm020964w
Side-chain conformational entropy at protein-protein interfaces DOI: 10.1110/ps.0222702
The structural and spectroscopic basis for modelling prion protein interactions
A similarity model for the human angiogenic factor, thymidine phosphorylase/platelet derived-endothelial cell growth factor
The role of thymidine phosphorylase/PD-ECGF in cancer chemotherapy: A chemical perspective
Evaluation of tools for differential gene expression analysis by RNA-seq on a 48 biological replicate experiment
Statistical models for RNA-seq data derived from a two-condition 48-replicate experiment
JPred4: a protein secondary structure prediction server. PMID: 25883141
Loss-of-Function Mutations in CAST Cause Peeling Skin, Leukonychia, Acral Punctate Keratoses, Cheilitis, and Knuckle Pads. PMID: 25683118
14-3-3-Pred: Improved methods to predict 14-3-3-binding phosphopeptides. PMID: 25735772
Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis. PMID: 24880632
Improved annotation of 3' untranslated regions and complex loci by combination of strand-specific direct RNA sequencing, RNA-Seq and ESTs. PMID: 24722185
Transcription termination and chimeric RNA formation controlled by Arabidopsis thaliana FPA. DOI: 10.1371/journal.pgen.1003867