Bertrand Tanner

Publications

• Remote sensing of surface energy fluxes at 101-m pixel resolutions
• Spatially explicit, nano-mechanical models of the muscle half-sarcomere: Implications for biomechanical tuning in atrophy and fatigue
• Comparative biomechanics of thick filaments and thin filaments with functional consequences for muscle contraction
• An inverse power-law distribution of molecular bond lifetimes predicts fractional derivative viscoelasticity in biological tissue
• Thick-to-thin filament surface distance modulates cross-bridge kinetics in Drosophila flight muscle
• COOH-terminal truncation of flightin decreases myofilament lattice organization, cross-bridge binding, and power output in Drosophila indirect flight muscle
• Random myosin loss along thick-filaments increases myosin attachment time and the proportion of bound myosin heads to mitigate force decline in skeletal muscle
• Filament compliance influences cooperative activation of thin filaments and the dynamics of force production in skeletal muscle
• A spatially explicit model of muscle contraction explains a relationship between activation phase, power and ATP utilization in insect flight
• Virus infection rapidly activates the P58IPK pathway, delaying peak kinase activation to enhance viral replication
• Myosin MgADP release rate decreases at longer sarcomere length to prolong myosin attachment time in skinned rat myocardium
• Cardiac myosin isoforms exhibit differential rates of MgADP release and MgATP binding detected by myocardial viscoelasticity
• Functional significance of C-terminal mobile domain of cardiac troponin I
• Effects of myosin light chain phosphorylation on length-dependent myosin kinetics in skinned rat myocardium
• Sarcomere lattice geometry influences cooperative myosin binding in muscle
• Myosin MgADP Release Rate Decreases as Sarcomere Length Increases in Skinned Rat Soleus Muscle Fibers
• Flightin maintains myofilament lattice organization required for optimal flight power and courtship song quality in Drosophila
• Measuring myosin cross-bridge attachment time in activated muscle fibers using stochastic vs. sinusoidal length perturbation analysis
• Dynamics and control of biomolecules: Research venues and opportunities
• Kinetics of cardiac myosin isoforms in mouse myocardium are affected differently by presence of myosin binding protein-C
• Increased Titin Compliance Reduced Length-Dependent Contraction and Slowed Cross-Bridge Kinetics in Skinned Myocardial Strips from Rbm20ΔRRM Mice
• Ex-vivo quantification of ovine pia arachnoid complex biomechanical properties under uniaxial tension
• RLC phosphorylation amplifies Ca2+ sensitivity of force in myocardium from cMyBP-C knockout mice
• Design Principles and Benefits of Spatially Explicit Models of Myofilament Function
• MgADP Promotes Myosin Head Movement toward Actin at Low [Ca2+] to Increase Force Production and Ca2+-Sensitivity of Contraction in Permeabilized Porcine Myocardial Strips
• The spatial distribution of thin filament activation influences force development and myosin activity in computational models of muscle contraction
• Effects of mavacamten on Ca2+ sensitivity of contraction as sarcomere length varied in human myocardium
• Effects of cross-bridge compliance on the force-velocity relationship and muscle power output
• Sarcomere length–dependent effects on Ca2+-troponin regulation in myocardium expressing compliant titin
• Regulatory light chain phosphorylation augments length-dependent contraction in PTU-treated rats
• Omecamtiv Mecarbil Slows Myosin Kinetics in Skinned Rat Myocardium at Physiological Temperature
• Demembranated skeletal and cardiac fibers produce less force with altered cross-bridge kinetics in a mouse model for limb-girdle muscular dystrophy 2i
• Enhancing diastolic function by strain-dependent detachment of cardiac myosin crossbridges
• Mavacamten decreases maximal force and Ca2+ sensitivity in the N47K-myosin regulatory light chain mouse model of hypertrophic cardiomyopathy
• Sarcomere length affects Ca2+ sensitivity of contraction in ischemic but not non-ischemic myocardium
• Cardiac myosin binding protein-C phosphorylation accelerates β-cardiac myosin detachment rate in mouse myocardium
• Myosin cross-bridge kinetics slow at longer muscle lengths during isometric contractions in intact soleus from mice
• Strain rate of stretch affects crossbridge detachment during relaxation of intact cardiac trabeculae.
• Danicamtiv affected isometric force and cross-bridge kinetics similarly in skinned myocardial strips from male and female rats
• The structural and functional effects of myosin regulatory light chain phosphorylation are amplified by increases in sarcomere length and [Ca2+]