Andrew Mcintosh

0000-0002-0198-4588

Academic Psychiatrist

Edinburgh, UK

Publications

Early life predictors of late life cerebral small vessel disease in four prospective cohort studies
SNP and Haplotype Regional Heritability Mapping (SNHap-RHM): joint mapping of common and rare variation affecting complex traits
Genome-wide interaction study with major depression identifies novel variants associated with cognitive function.
Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis
Statins and antidepressants induce similar in vitro gene expression responses
Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank
Participation and item missingness in a depression questionnaire in Generation Scotland: The Scottish Family Health Study
Classification accuracy of structural and functional connectomes across different depressive phenotypes
Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression
Acute COVID-19 severity and 16-month mental morbidity trajectories in patient populations of six nations
Methodological Considerations When Using Polygenic Scores to Explore Parent-Offspring Genetic Nurturing Effects
Childhood cognitive ability and self-harm and suicide in later life
Investigating the potential anti-depressive mechanisms of statins: a transcriptomic and Mendelian randomization analysis
The epidemiological characteristics of stroke phenotypes defined with ICD-10 and free-text: a cohort study linked to electronic health records
Integration of DNA methylation datasets for individual prediction
Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk
Epigenetic contributions to clinical risk prediction of cardiovascular disease
Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids
Pathway-based polygenic risk scores for schizophrenia and associations with clinical and neuroimaging phenotypes in UK Biobank
Age and sex‐related variability in the presentation of generalized anxiety and depression symptoms
Comparing personalized brain-based and genetic risk scores for major depressive disorder in large population samples of adults and adolescents
Structural neuroimaging measures and lifetime depression across levels of phenotyping in UK biobank
Correction: Structural neuroimaging measures and lifetime depression across levels of phenotyping in UK biobank
Cohort profile: The Scottish SHARE Mental Health (SHARE-MH) cohort – linkable survey, genetic and routinely collected data for mental health research
Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants
Socioeconomic Status and Depression – A Systematic Review
Predicting sex, age, general cognition and mental health with machine learning on brain structural connectomes
TeenCovidLife: a resource to understand the impact of the COVID-19 pandemic on adolescents in Scotland [version 2; peer review: 2 approved]
Childhood intelligence and risk of depression in later-life: A longitudinal data-linkage study
Genetic examination of the Mood Disorder Questionnaire and its relationship with bipolar disorder
Methylome-wide association studies of traumatic injury identifies differential DNA methylation of synaptic plasticity and GABAergic-signalling
Characterisation and Genetic Architecture of Major Depressive Disorder Subgroups Defined by Weight and Sleep Changes
Comprehensive assessment of sleep duration, insomnia, and brain structure within the UK Biobank cohort
The circulating proteome and brain health: Mendelian randomisation and cross-sectional analyses
Childhood intelligence and risk of depression in later-life: A longitudinal data-linkage study
The effects of CYP2C19 metaboliser status on DNA methylation
Early-life inflammatory markers and subsequent episodes of depression and psychotic experiences in the ALSPAC birth cohort
Genetic stratification of depression by neuroticism: revisiting a diagnostic tradition
Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments [version 2; peer review: 2 approved]
Longitudinal trajectories of brain age in young individuals at familial risk of mood disorder from the Scottish Bipolar Family Study [version 3; peer review: 3 approved]
Associations Between Major Psychiatric Disorder Polygenic Risk Scores and Blood-Based Markers in UK Biobank
Associations between alcohol use and accelerated biological ageing
The Influence of Phenotyping Method on Structural Neuroimaging Associations with Depression in UK Biobank
Experience of clinical services shapes attitudes to mental health data sharing: Findings from a UK-wide survey
Co-development of a best practice checklist for mental health data science: A Delphi study
Novel polygenic risk score links depression-related cortical transcriptomic changes to brain morphology and symptom severity
Face covering adherence is positively associated with better mental health and wellbeing: a longitudinal analysis of the CovidLife surveys [version 1; peer review: 1 approved, 1 approved with reservations]
Genome-wide methylation data improves dissection of the effect of smoking on body mass index
CovidLife: a resource to understand mental health, well-being and behaviour during the COVID-19 pandemic in the UK [version 1; peer review: 2 approved]
RuralCovidLife: A new resource for the impact of the pandemic on rural Scotland [version 2; peer review: 2 approved]
Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression
Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP
Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health, and longer life
Birth weight associations with DNA methylation differences in an adult population
Epigenome-wide association study and multi-tissue replication of individuals with alcohol use disorder: evidence for abnormal glucocorticoid signaling pathway gene regulation
Greater male than female variability in regional brain structure across the lifespan
CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake
Cognitive functioning and lifetime major depressive disorder in UK Biobank
Automated classification of depression from structural brain measures across two independent community-based cohorts
Pharmacoepidemiology research: delivering evidence about drug safety and effectiveness in mental health
Genetic stratification of depression in UK Biobank
Genetic copy number variants, cognition and psychosis: a meta-analysis and a family study
Complement genes contribute sex-biased vulnerability in diverse disorders
Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
In vivo hippocampal subfield volumes in bipolar disorder—A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group
Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders: Evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group
Comparison of rule-based and neural network models for negation detection in radiology reports
Bayesian reassessment of the epigenetic architecture of complex traits
A genome-wide association study finds genetic variants associated with neck or shoulder pain in UK Biobank
DNA methylation in APOE: The relationship with Alzheimer's and with cardiovascular health
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder
Author Correction: Bayesian reassessment of the epigenetic architecture of complex traits (Nature Communications, (2020), 11, 1, (2865), 10.1038/s41467-020-16520-1)
Genetic comorbidity between major depression and cardio-metabolic traits, stratified by age at onset of major depression
A large-scale genome-wide association study meta-analysis of cannabis use disorder
Characterisation of an inflammation-related epigenetic score and its association with cognitive ability
DNA methylation outlier burden, health, and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936
Epigenetic prediction of major depressive disorder
Epigenetic age acceleration and cognitive function in African American adults in Midlife: The atherosclerosis risk in communities study
Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden
Erratum: Author Correction: Genome-wide association study of knee pain identifies associations with GDF5 and COL27A1 in UK Biobank (Communications biology (2019) 2 (321))
Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank (Molecular Psychiatry, (2020), 10.1038/s41380-019-0546-6)
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
Blunted medial prefrontal cortico-limbic reward-related effective connectivity and depression
Genome-wide association study of suicide death and polygenic prediction of clinical antecedents
An automated machine learning approach to predict brain age from cortical anatomical measures
Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples
Educational attainment reduces the risk of suicide attempt among individuals with and without psychiatric disorders independent of cognition: a bidirectional and multivariable Mendelian randomization study with more than 815,000 participants
Expression quantitative trait loci-derived scores and white matter microstructure in UK Biobank: a novel approach to integrating genetics and neuroimaging
Genetic correlations between pain phenotypes and depression and neuroticism
Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression
Aberrant structural covariance networks in youth at high familial risk for mood disorder
Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity
Epigenetic clocks predict prevalence and incidence of leading causes of death and disease burden
Using a knowledge exchange event to assess study participants’ attitudes to research in a rapidly evolving research context [version 2; peer review: 3 approved]
GWAS of Depression Phenotypes in the Million Veteran Program and Meta-analysis in More than 1.2 Million Participants Yields 178 Independent Risk Loci
Sex-Stratified Genome-Wide Association Study of Multisite Chronic Pain in UK Biobank
Genetic Architecture of 11 Major Psychiatric Disorders at Biobehavioral, Functional Genomic, and Molecular Genetic Levels of Analysis
Genome-wide methylation data improves dissection of the effect of smoking on body mass index
Longitudinal trajectories of brain age in young individuals at familial risk of mood disorder from the Scottish Bipolar Family Study
Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish Population
Predicting major mental illness: ethical and practical considerations
White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group
Genome-wide association study of multisite chronic pain in UK biobank
Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures
Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte–myelin dysfunction
An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort
Assessment of dried blood spots for DNA methylation profiling [version 1; peer review: 2 approved]
Author Correction: Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism (Nature Genetics, (2018), 50, 1, (6-11), 10.1038/s41588-017-0013-8)
10kin1day: A bottom-up neuroimaging initiative
Subthreshold psychosis symptoms associated with molecular genetic risk in a population-based cohort: Findings from Generation Scotland
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
A meta-analysis of genome-wide association studies of epigenetic age acceleration.
Identification of novel common variants associated with chronic pain using conditional false discovery rate analysis with major depressive disorder and assessment of pleiotropic effects of LRFN5
Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function (Nature Communications, (2018), 9, 1, (2098), 10.1038/s41467-018-04362-x)
Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank
Childhood intelligence attenuates the association between biological ageing and health outcomes in later life
Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population
A polygenic resilience score moderates the genetic risk for schizophrenia
The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls
Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780,000 participants
An epigenome-wide association study of sex-specific chronological ageing
Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income
Using a knowledge exchange event to assess study participants' attitudes to research in a rapidly evolving research context
Correction: Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals (Neuropsychopharmacology, (2019), 44, 13, (2285-2293), 10.1038/s41386-019-0485-6)
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders
Genetic architecture of subcortical brain structures in 38,851 individuals
Assessment of bidirectional relationships between physical activity and depression among adults a 2-sample Mendelian randomization study
An epigenetic predictor of death captures multi-modal measures of brain health
Psychotic-like experiences, polygenic risk scores for schizophrenia, and structural properties of the salience, default mode, and central-executive networks in healthy participants from UK Biobank
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies
A major role for common genetic variation in anxiety disorders
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
Genome-wide association study identifies 30 loci associated with bipolar disorder
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism [version 2; referees: 1 approved, 2 approved with reservations]
Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland
Conditioning on a Collider May or May Not Explain the Relationship Between Lower Neuroticism and Premature Mortality in the Study by Gale et al. (2017): A Reply to Richardson, Davey Smith, and Munafò (2019)
Genome-wide association study meta-analysis of the alcohol use disorders identification test (AUDIT) in two population-based cohorts
A validation of the diathesis-stress model for depression in Generation Scotland
Genome-wide association study of knee pain identifies associations with GDF5 and COL27A1 in UK Biobank
Associations between vascular risk factors and brain MRI indices in UK Biobank
A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence
Rediscovering the value of families for psychiatric genetics research
Educational attainment impacts drinking behaviors and risk for alcohol dependence: results from a two-sample Mendelian randomization study with ~780 000 participants
Cognitive functioning and lifetime Major Depressive Disorder in UK Biobank
DNA methylation in the APOE gene: its link with Alzheimer’s and cardiovascular health
Factors associated with sharing e-mail information and mental health survey participation in large population cohorts
Longitudinal trajectories of brain age in young individuals at familial risk of mood disorder
The role of neuroticism in self-harm and suicidal ideation: results from two UK population-based cohorts
A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains
Brain cortical characteristics of lifetime cognitive ageing
Associations between psychosis endophenotypes across brain functional, structural, and cognitive domains
Association between schizophrenia-related polygenic liability and the occurrence and level of mood-incongruent psychotic symptoms in bipolar disorder
Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism [version 1; referees: 3 approved with reservations]
Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
The Genetic Links to Anxiety and Depression (GLAD) Study: Online recruitment into the largest recontactable study of depression and anxiety
Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging
Age at first birth in women is genetically associated with increased risk of schizophrenia
A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework
Addendum: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways
Cohort profile: Stratifying Resilience and Depression Longitudinally (STRADL): A questionnaire follow-up of Generation Scotland: Scottish Family Health Study (GS: SFHS)
Analysis of shared heritability in common disorders of the brain
Altered DNA methylation associated with a translocation linked to major mental illness
No alterations of brain structural asymmetry in major depressive disorder: An ENIGMA consortium analysis
Relationship between neuropsychiatric disorders and cognitive and behavioural change in MND
How data science can advance mental health research
Indicators of mental disorders in UK Biobank—A comparison of approaches
Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD
Publisher Correction: Parent of origin genetic effects on methylation in humans are common and influence complex trait variation (Nature Communications, (2019), 10, 1, (1383), 10.1038/s41467-019-09301-y)
Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?
Identification of common genetic risk variants for autism spectrum disorder
Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia
The Neurobiology of Personal Control During Reward Learning and Its Relationship to Mood
Quantifying between-cohort and between-sex genetic heterogeneity in major depressive disorder
Low-frequency variation in TP53 has large effects on head circumference and intracranial volume
Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
The influence of X chromosome variants on trait neuroticism
Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder
Uncovering the Genetic Architecture of Major Depression
Pharmaco-epidemiology of antidepressant exposure in a UK cohort record-linkage study
Insulin resistance: Genetic associations with depression and cognition in population based cohorts
Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits
Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (Nature Genetics, (2019), 51, 4, (659-674), 10.1038/s41588-019-0364-4)
Impact of Polygenic Risk for Schizophrenia on Cortical Structure in UK Biobank
White Matter Microstructure and Its Relation to Longitudinal Measures of Depressive Symptoms in Mid- and Late Life
Transplanted t(1;11) patient-derived OPCs form shorter myelin internodes in the hypomyelinated shiverer mice
Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection (Nature Genetics, (2018), 50, 3, (381-389), 10.1038/s41588-018-0059-2)
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals
Self-reported medication use validated through record linkage to national prescribing data
Genomic analysis of family data reveals additional genetic effects on intelligence and personality
Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder
A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (N = 223,773)
Resting-State Connectivity and Its Association With Cognitive Performance, Educational Attainment, and Household Income in the UK Biobank
A validation of the diathesis-stress model for depression in Generation Scotland
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
Genetic risk of major depressive disorder: The moderating and mediating effects of neuroticism and psychological resilience on clinical and self-reported depression
Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank
Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data
Data Resource Profile: Generation Scotland Electronic Health Record
Polygenic risk for schizophrenia, transition and cortical gyrification: A high-risk study
Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
Rare disruptive variants in the DISC1 Interactome and Regulome: Association with cognitive ability and schizophrenia
DNA sequence-level analyses reveal potential phenotypic modifiers in a large family with psychiatric disorders
Epigenetic prediction of complex traits and death
DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness
DNA methylation signatures of depressive symptoms in middle-aged and elderly persons: Meta-analysis of multiethnic epigenome-wide studies
Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood
Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression
Genetic contributions to Trail Making Test performance in UK Biobank
Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's disease
Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium
Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium
Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways
Cortical abnormalities in bipolar disorder: An MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group
Diffusion tensor imaging correlates of early markers of depression in youth at high-familial risk for bipolar disorder
Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability
Do depression and stressful events cause premature aging?
Sex differences in the adult human brain: Evidence from 5216 UK biobank participants
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
Epigenetic signatures of starting and stopping smoking
Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing
Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder
The Stratification Of Major Depressive Disorder Into Genetic Subgroups
Genome-Wide Meta-Analyses Of Stratified Depression In Generation Scotland And UK Biobank
Genetic and environmental contributions to psychological resilience and coping [version 1; referees: 2 approved]
Mental health in UK Biobank: Development, implementation and results from an online questionnaire completed by 157 366 participants
Corrigendum: Mental health in UK Biobank: Development, implementation and results from an online questionnaire completed by 157 366 participants (BJPsych Open (2018) 4:3 (83-90) DOI: 10.1192/bjo.2018.12)
Corrigendum: Mental health in UK Biobank: Development, implementation and results from an online questionnaire completed by 157 366 participants (BJPsych Open (2018) 4:3 (83-90) DOI: 10.1192/bjo.2018.12)
Genetic contributions to self-reported tiredness
A Combined Pathway and Regional Heritability Analysis Indicates NETRIN1 Pathway Is Associated With Major Depressive Disorder
An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype
Electronic health record and genome-wide genetic data in Generation Scotland participants
Chronic pain, depression and cardiovascular disease linked through a shared genetic predisposition: Analysis of a family-based cohort and twin study
The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability
Genetic contribution to two factors of neuroticism is associated with affluence, better health, and longer life
A combined analysis of genetically correlated traits identifies 107 loci associated with intelligence
Genetic contributions to trail making test performance in UK Biobank
Genomic analysis of family data reveals additional genetic effects on intelligence and personality
Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).
Increased gyrification in schizophrenia and non affective first episode of psychosis
Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group
Assessing the presence of shared genetic architecture between Alzheimer's disease and major depressive disorder using genome-wide association data
Genetic association of major depression with a typical features and obesity-related immunometabolic dysregulations
Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank
Verbal working memory and functional large-scale networks in schizophrenia
Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank
When Is Higher Neuroticism Protective Against Death? Findings From UK Biobank
Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK biobank (N=112117)
Genetic and environmental risk for chronic pain and the contribution of risk variants for psychiatric disorders. Results from Generation Scotland: Scottish Family Health Study and UK Biobank
Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity
Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes
Genetic effects influencing risk for major depressive disorder in China and Europe
Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia
Do regional brain volumes and major depressive disorder share genetic architecture? A study of Generation Scotland (n=19 762), UK Biobank (n=24 048) and the English Longitudinal Study of Ageing (n=5766)
Balanced translocation linked to psychiatric disorder, glutamate, and cortical structure/function
Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis
Associations between single andmultiple cardiometabolic diseases and cognitive abilities in 474 129 UK Biobank participants
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
Molecular genetic contributions to self-rated health
Longitudinal differences in white matter integrity in youth at high familial risk for bipolar disorder
Childhood adversity and cortical thickness and surface area in a population at familial high risk of schizophrenia
Erratum: Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium (Molecular Psychiatry (2015) DOI:10.1038/mp.2015.63)
Age-Dependent Pleiotropy Between General Cognitive Function and Major Psychiatric Disorders
Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population
Data science for mental health: a UK perspective on a global challenge
Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: Evidence from voxel-based meta-analysis
Deactivation in anterior cingulate cortex during facial processing in young individuals with high familial risk and early development of depression: fMRI findings from the Scottish Bipolar Family Study
DNA methylation in a Scottish family multiply affected by bipolar disorder and major depressive disorder
Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder
Effects of environmental risks and polygenic loading for schizophrenia on cortical thickness
Computational meta-analysis of statistical parametric maps in major depression
Invited Commentary on Stewart and Davis “ ‘Big data’ in mental health research—current status and emerging possibilities”
Childhood adversity and hippocampal and amygdala volumes in a population at familial high risk of schizophrenia
Using Polygenic Risk Scores to Establish Endophenotypes: Considerations and Current Constraints
Cardiometabolic disease and features of depression and bipolar disorder: Population-based, cross-sectional study
Early-life predictors of resilience and related outcomes up to 66 years later in the 6-day sample of the 1947 Scottish mental survey
Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research
Novel genetic loci associated with hippocampal volume
Genetic and Environmental Risk for Chronic Pain and the Contribution of Risk Variants for Major Depressive Disorder: A Family-Based Mixed-Model Analysis
Alzheimer disease genetic risk factor APOE e4 and cognitive abilities in 111,739 UK Biobank participants
Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts
Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group
Investigating shared aetiology between type 2 diabetes and major depressive disorder in a population based cohort
Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank
Cognitive test scores in UK biobank: Data reduction in 480,416 participants and longitudinal stability in 20,346 participants
Correction: Cognitive test scores in UK biobank: Data reduction in 480,416 participants and longitudinal stability in 20,346 participants
Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Genetic contributions to self-reported tiredness
Intelligence and neuroticism in relation to depression and psychological distress: Evidence from two large population cohorts
TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport
Consent for brain tissue donation after intracerebral haemorrhage: A community- Based study
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
Preliminary investigation of miRNA expression in individuals at high familial risk of bipolar disorder
Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort
Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder
Pleiotropy between neuroticism and physical and mental health: Findings from 108038 men and women in UK biobank
The UK10K project identifies rare variants in health and disease
Subcortical brain alterations in major depressive disorder: Findings from the ENIGMA Major Depressive Disorder working group
Structural magnetic resonance imaging markers of susceptibility and transition to schizophrenia: A review of familial and clinical high risk population studies
Impact of cross-disorder polygenic risk on frontal brain activation with specific effect of schizophrenia risk
Cortical thickness in individuals at high familial risk of mood disorders as they develop major depressive disorder
Cortical Surface Area Differentiates Familial High Risk Individuals Who Go on to Develop Schizophrenia
Ethnic differences in the association between depression and chronic pain: Cross sectional results from UK Biobank Clinical presentation, diagnosis, and management
New data and an old puzzle: The negative association between schizophrenia and rheumatoid arthritis
Rare coding variants and X-linked loci associated with age at menarche
Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium
Heritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
Effects of a balanced translocation between chromosomes 1 and 11 disrupting the DISC1 locus on white matter integrity
Common genetic variants influence human subcortical brain structures
Current versus lifetime depression, APOE variation, and their interaction on cognitive performance in younger and older adults
The association between lower educational attainment and depression owing to shared genetic effects? Results in ∼25 000 subjects
Dysfunction of emotional brain systems in individuals at high risk of mood disorder with depression and predictive features prior to illness
Family load impacts orbitofrontal volume in first-episode schizophrenia
Neurocognition in individuals at high familial risk of mood disorders with or without subsequent onset of depression
Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort
Subcortical volumetric abnormalities in bipolar disorder
Preliminary assessment of pre-morbid DNA methylation in individuals at high genetic risk of mood disorders
Cognitive function and lifetime features of depression and bipolar disorder in a large population sample: Cross-sectional study of 143,828 UK Biobank participants
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study
Prospective longitudinal voxel-based morphometry study of major depressive disorder in young individuals at high familial risk
Genetic influences on schizophrenia and subcortical brain volumes: Large-scale proof of concept
Epidemiology and heritability of major depressive disorder, stratified by age of onset, sex, and illness course in generation Scotland: Scottish family health study (GS: SFHS)
Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151)
Major depressive disorder and current psychological distress moderate the effect of polygenic risk for obesity on body mass index
LD score regression distinguishes confounding from polygenicity in genome-wide association studies
Polygenic risk for coronary artery disease is associated with cognitive ability in older adults
Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci
Novel genetic loci underlying human intracranial volume identified through genome-wide association
Psychological distress, neuroticism, and cause-specific mortality: Early prospective evidence from UK Biobank
Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders
Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N=112 151) and 24 GWAS consortia
Shared Genetics and Couple-Associated Environment Are Major Contributors to the Risk of Both Clinical and Self-Declared Depression
Identification of polymorphic and off-target probe binding sites on the Illumina Infinium MethylationEPIC BeadChip
Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel
Prospective longitudinal study of subcortical brain volumes in individuals at high familial risk of mood disorders with or without subsequent onset of depression
Response to Dr Fried & Dr Kievit, and Dr Malhi et al.
Molecular Genetic Contributions to Social Deprivation and Household Income in UK Biobank
Social responsiveness to inanimate entities: Altered white matter in a ‘social synaesthesia’
Effect of Variation in Diacylglycerol Kinase Eta (DGKH) Gene on Brain Function in a Cohort at Familial Risk of Bipolar Disorder
White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder.
Activation During Angry Face Processing Differentiates Bipolar Relatives with Mood Disorders from those without
Schizophrenia genetic variants are not associated with intelligence
Variability inworking memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway
A mega-analysis of genome-wide association studies for major depressive disorder
Genetic schizophrenia risk variants jointly modulate total brain and white matter volume
A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation
Prediction of depression in individuals at high familial risk of mood disorders using functional magnetic resonance imaging.
Anterior cingulate morphology in people at genetic high-risk of schizophrenia
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Diffusion Tensor Imaging (DTI) Markers of Vulnerability for Mood Disorder: Evidence from Population Cohort Shows Modulation by Neuroticism
Cognitive endophenotypes in a family with bipolar disorder with a risk locus on chromosome 4
Functional Imaging of Emotional Memory in Individuals at High Familial Risk of Bipolar Disorder with and without Depression
An investigation of a genomewide supported psychosis variant in ZNF804A and white matter integrity in the human brain
Common and distinct neural correlates of emotional processing in Bipolar Disorder and Major Depressive Disorder: A voxel-based meta-analysis of functional magnetic resonance imaging studies
Neuroticism, depressive symptoms and white-matter integrity in the Lothian Birth Cohort 1936
The effect of long-term high frequency repetitive transcranial magnetic stimulation on working memory in schizophrenia and healthy controls-A randomized placebo-controlled, double-blind fMRI study
Effects of a mis-sense DISC1 variant on brain activation in two cohorts at high risk of bipolar disorder or schizophrenia
Is bipolar disorder more common in highly intelligent people? A cohort study of a million men
Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: A pilot project of the ENIGMA-DTI working group
Polygenic Risk and White Matter Integrity in Individuals at High Risk of Mood Disorder
Progress in imaging the effects of psychosis susceptibility gene variants
Toward a Systems Biology of Mood Disorder
White matter integrity as an intermediate phenotype: Exploratory genome-wide association analysis in individuals at high risk of bipolar disorder
A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins
Biological insights from 108 schizophrenia-associated genetic loci
Two-back makes step forward in brain imaging genomics
White matter integrity and its association with affective and interpersonal symptoms in borderline personality disorder
Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling
The ENIGMA Consortium: Large-scale collaborative analyses of neuroimaging and genetic data
DISC1 as a genetic risk factor for schizophrenia and related major mental illness: Response to Sullivan
Corrigendum to Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: A pilot project of the ENIGMA-DTI working group [NeuroImage 81 (2013) 455-469]
A survey of rare coding variants in candidate genes in schizophrenia by deep sequencing
Polygenic risk for schizophrenia is associated with cognitive change between childhood and old age
Chronic multisite pain in major depression and bipolar disorder: Cross-sectional study of 149,611 participants in UK Biobank
Altered amygdala connectivity within the social brain in schizophrenia
A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans
708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: Analysis for association with psychiatric disorder and cognitive traits
White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder.
Tensor-based morphometry of cannabis use on brain structure in individuals at elevated genetic risk of schizophrenia
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
Cortical thickness in first-episode schizophrenia patients and individuals at high familial risk: A cross-sectional comparison
Transcranial Magnetic Stimulation for Schizophrenia
The cortical thickness phenotype of individuals with DISC1 translocation resembles schizophrenia
Whole-genome sequence-based analysis of thyroid function
Combining Meta- and mega-analytic approaches for multi-site diffusion imaging based genetic studies: From the enigma-DTI working group
Transcranial magnetic stimulation (TMS) for schizophrenia
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
Identification of pathways for bipolar disorder: A meta-analysis
Effects of the BDNF Val66Met polymorphism on neural responses to facial emotion
Runs of homozygosity implicate autozygosity as a schizophrenia risk factor
Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: A polygenic risk score analysis
DISC1 in Schizophrenia: Genetic Mouse Models and Human Genomic Imaging
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
Prediction of Mood Disorder in Those at Familial Risk using fMRI
Prefrontal cortex gyrification index in twins: an MRI study
The classification of psychosis reply
Can we define a functional neuroanatomy of bipolar disorder?
Schizophrenia risk genes: Implications for future drug development and discovery
The effects of DISC1 risk variants on brain activation in controls, patients with bipolar disorder and patients with schizophrenia
The functional neuroanatomy of bipolar disorder: a consensus model
Do we have any solid evidence of clinical utility about the pathophysiology of schizophrenia?
Genome-wide association study identifies five new schizophrenia loci
Identification of common variants associated with human hippocampal and intracranial volumes
Impact of cannabis use on thalamic volume in people at familial high risk of schizophrenia
Longitudinal Volume Reductions in People at High Genetic Risk of Schizophrenia as They Develop Psychosis
Predicting first episode psychosis in those at high risk for genetic or cognitive reasons
Review of functional magnetic resonance imaging studies comparing bipolar disorder and schizophrenia
Structural Magnetic Resonance Imaging in Bipolar Disorder: An International Collaborative MegaAnalysis of Individual Adult Patient Data
THE IMPACT OF SUBSTANCE USE ON BRAIN STRUCTURE IN PEOPLE AT GENETICALLY HIGH RISK OF SCHIZOPHRENIA
The influence of polygenic risk for bipolar disorder on neural activation assessed using fMRI
Grey matter differences in bipolar disorder: a meta-analysis of voxel-based morphometry studies
Genetic Variation in ANK3 and Frontotemporal Structural and Functional Connectivity in Bipolar Disorder
Imaging genetic risk in bipolar disorder
Impact of a microRNA MIR137 Susceptibility Variant on Brain Function in People at High Genetic Risk of Schizophrenia or Bipolar Disorder
Lower effective connectivity between amygdala and parietal regions in response to fearful faces in schizophrenia
Magnetic resonance imaging studies in unipolar depression: Systematic review and meta-regression analyses
Social Cognition, the Male Brain and the Autism Spectrum
Use of second-person pronouns and schizophrenia
Are There Progressive Brain Changes in Schizophrenia? A Meta-Analysis of Structural Magnetic Resonance Imaging Studies
Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorder
Association of white matter integrity with genetic variation in an exonic DISC1 SNP
Genetic Variation in CNTNAP2 Alters Brain Function During Linguistic Processing in Healthy Individuals
Genetic variants in the ErbB4 gene are associated with white matter integrity
The association of genetic variation in CACNA1C with structure and function of a frontotemporal system
Quantifying the RR of harm to self and others from substance misuse: Results from a survey of clinical experts across Scotland
Genetic variation in hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition, and risk of depression
White matter integrity in individuals at high genetic risk of bipolar disorder
The neural basis of familial risk and temperamental variation in individuals at high risk of bipolar disorder
The impact of substance use on brain structure in people at high risk of developing schizophrenia
Do we have any solid evidence of clinical utility about the pathophysiology of schizophrenia?,Czy mamy jakieś solidne, przydatneklinicznie dowody naukowe dotyczaçe patofizjologii schizofrenii?
Do we have any solid evidence of clinical utility about the pathophysiology of schizophrenia?
Functional magnetic resonance imaging of BDNF val66met polymorphism in unmedicated subjects at high genetic risk of schizophrenia performing a verbal memory task
Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task
Effects of the BDNF val66met polymorphism on prefrontal brain function in a population at high genetic risk of schizophrenia
Hippocampal and amygdala volumes in borderline personality disorder: A meta-analysis of magnetic resonance imaging studies
Between- and within-scanner variability in the CaliBrain study n-back cognitive task
A common neural system mediating two different forms of social judgement
Reduced white matter integrity in healthy individuals carrying the A-allele at DISC1 Ser704Cys
Transcranial magnetic stimulation for schizophrenia
Hypofrontality in subjects at high genetic risk of schizophrenia with depressive symptoms
The 'continuum of psychosis': Scientifically unproven and clinically impractical
Reduced prefrontal gyrification in obsessive-compulsive disorder
Orbitofrontal morphology in people at high risk of developing schizophrenia
Midbrain activation during pavlovian conditioning and delusional symptoms in schizophrenia
Hippocampal function in schizophrenia and bipolar disorder
Progressive temporal lobe grey matter loss in adolescents with schizotypal traits and mild intellectual impairment
Connecting the brain and new drug targets for schizophrenia
Changes in Gyrification Over 4 Years in Bipolar Disorder and Their Association with the Brain-Derived Neurotrophic Factor Valine66 Methionine Variant
Working memory in schizophrenia: A meta-analysis
White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging
The relationship of anterior thalamic radiation integrity to psychosis risk associated neuregulin-1 variants
Structural abnormalities of ventrolateral and orbitofrontal cortex in patients with familial bipolar disorder
Specific cognitive deficits in a group at genetic high risk of schizophrenia
Set shifting and reversal learning in patients with bipolar disorder or schizophrenia
Segmentation of the anterior thalamic radiation using neighbourhood tractography
Prospective multi-centre voxel based morphometry study employing scanner specific segmentations: Procedure development using CaliBrain structural MRI data
Prefrontal gyral folding and its cognitive correlates in bipolar disorder and schizophrenia
Obstetric complications and mild to moderate intellectual disability
Modulation of hippocampal activation by genetic variation in the GRIK4 gene
A GRIK4 variant conferring protection against bipolar disorder modulates hippocampal function
White Matter Tractography in Bipolar Disorder and Schizophrenia
Meta-analysis of magnetic resonance imaging studies in chromosome 22q11.2 deletion syndrome (velocardiofacial syndrome)
Magnetic resonance imaging studies in bipolar disorder and schizophrenia: Meta-analysis
Genetic variation in the G72 (DAOA) gene affects temporal lobe and amygdala structure in subjects affected by bipolar disorder
Genetic risk for white matter abnormalities in bipolar disorder
Functional imaging of emotional memory in bipolar disorder and schizophrenia
fMRI changes over time and reproducibility in unmedicated subjects at high genetic risk of schizophrenia
Associative learning and the genetics of schizophrenia
The effects of a neuregulin 1 variant on white matter density and integrity
Prefrontal function and activation in bipolar disorder and schizophrenia
Towards a neuroanatomy of autism: A systematic review and meta-analysis of structural magnetic resonance imaging studies
The rate of usage of electroconvulsive therapy in the city of Edinburgh, 1993-2005
Overactivation of Fear Systems to Neutral Faces in Schizophrenia
Meta-analysis of magnetic resonance imaging studies of the corpus callosum in schizophrenia
Meta-analysis of magnetic resonance imaging studies of the corpus callosum in bipolar disorder
Low birthweight and preterm birth in young people with special educational needs: A magnetic resonance imaging analysis
Neuroimaging and molecular genetics of schizophrenia: Pathophysiological advances and therapeutic potential
Meta-analysis of magnetic resonance imaging studies of the corpus callosum in schizophrenia,Metaanálisis de estudios sobre resonancia magnética del cuerpo calloso en la esquizofrenia
Brain structure and function changes during the development of schizophrenia: The evidence from studies of subjects at increased genetic risk
Progressive Gray Matter Loss in Patients with Bipolar Disorder
Genetic Variation in the DAOA (G72) Gene Modulates Hippocampal Function in Subjects at High Risk of Schizophrenia
A diffusion tensor MRI study of white matter integrity in subjects at high genetic risk of schizophrenia
Temporal grey matter reductions in bipolar disorder are associated with the BDNF Val66Met polymorphism [7]
Relationship of Catechol-O-Methyltransferase Variants to Brain Structure and Function in a Population at High Risk of Psychosis
Correlations between fMRI activation and individual psychotic symptoms in un-medicated subjects at high genetic risk of schizophrenia
Increased Prefrontal Gyrification in a Large High-Risk Cohort Characterizes Those Who Develop Schizophrenia and Reflects Abnormal Prefrontal Development
Grey matter correlates of early psychotic symptoms in adolescents at enhanced risk of psychosis: A voxel-based study
Compliance therapy for schizophrenia

Andrew Mcintosh

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