Alfonso Eirin

Publications

• Metabolic Syndrome Modulates Protein Import into the Mitochondria of Porcine Mesenchymal Stem Cells
• Impact of Serum Uric Acid Levels on Outcomes following Renal Artery Revascularization in Patients with Renovascular Disease
• Experimental Renovascular Disease Induces Endothelial Cell Mitochondrial Damage and Impairs Endothelium-Dependent Relaxation of Renal Artery Segments
• General Public’s Information-Seeking Patterns of Topics Related to Obesity: Google Trends Analysis (Preprint)
• Metabolic Syndrome Impairs 3D Mitochondrial Structure, Dynamics, and Function in Swine Mesenchymal Stem Cells
• General Public’s Information-Seeking Patterns of Topics Related to Obesity: Google Trends Analysis
• Metabolic Syndrome Alters the Cargo of Mitochondria-Related microRNAs in Swine Mesenchymal Stem Cell-Derived Extracellular Vesicles, Impairing Their Capacity to Repair the Stenotic Kidney
• Renovascular Hypertension Induces Myocardial Mitochondrial Damage, Contributing to Cardiac Injury and Dysfunction in Pigs With Metabolic Syndrome
• Duodenal mucosal mitochondrial gene expression is associated with delayed gastric emptying in diabetic gastroenteropathy
• Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles Elicit Better Preservation of the Intra-Renal Microvasculature Than Renal Revascularization in Pigs with Renovascular Disease
• Emergent players in renovascular disease
• Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and mitomiRs
• Microvascular remodeling and altered angiogenic signaling in human kidneys distal to occlusive atherosclerotic renal artery stenosis
• Renal Ischemia Induces Epigenetic Changes in Apoptotic, Proteolytic, and Mitochondrial Genes in Swine Scattered Tubular-like Cells
• Cellular senescence: the good, the bad and the unknown
• Effects of Elamipretide on Autophagy in Renal Cells of Pigs with Metabolic Syndrome
• Cardiac epigenetic changes in VEGF signaling genes associate with myocardial microvascular rarefaction in experimental chronic kidney disease
• Superimposition of metabolic syndrome magnifies post-stenotic kidney injury in dyslipidemic pigs
• Mesenchymal stem cell-Based therapy for chronic kidney disease
• Models of renovascular disease
• Membranous Nephropathy
• Coexisting renal artery stenosis and metabolic syndrome magnifies mitochondrial damage, aggravating poststenotic kidney injury in pigs
• Persistent kidney dysfunction in swine renal artery stenosis correlates with outer cortical microvascular remodeling
• Selective intrarenal delivery of mesenchymal stem cell-derived extracellular vesicles attenuates myocardial injury in experimental metabolic renovascular disease
• Cardiac Metabolic Alterations in Hypertensive Obese Pigs
• Integrated transcriptomic and proteomic analysis of the molecular cargo of extracellular vesicles derived from porcine adipose tissue-derived mesenchymal stem cells
• Next-Generation Morphometry for pathomics-data mining in histopathology
• Comparative proteomic analysis of extracellular vesicles isolated from porcine adipose tissue-derived mesenchymal stem/stromal cells
• Autologous Extracellular Vesicles Attenuate Cardiac Injury in Experimental Atherosclerotic Renovascular Disease More Effectively Than Their Parent Mesenchymal Stem/Stromal Cells
• Mitochondrial protection restores renal function in swine atherosclerotic renovascular disease
• Mitochondrial protection partly mitigates kidney cellular senescence in swine atherosclerotic renal artery stenosis
• Mesenchymal stem cell–derived extracellular vesicles induce regulatory T cells to ameliorate chronic kidney injury
• Intrarenal delivery of mesenchymal stem cells and endothelial progenitor cells attenuates hypertensive cardiomyopathy in experimental renovascular hypertension
• Clinical features of patients with immunoglobulin light chain amyloidosis (AL) with vascular-limited deposition in the kidney
• Hypoxic preconditioning induces epigenetic changes and modifies swine mesenchymal stem cell angiogenesis and senescence in experimental atherosclerotic renal artery stenosis
• Challenges and opportunities for stem cell therapy in patients with chronic kidney disease
• In a Phase 1a escalating clinical trial, autologous mesenchymal stem cell infusion for renovascular disease increases blood flow and the glomerular filtration rate while reducing inflammatory biomarkers and blood pressure
• Early podocyte injury and elevated levels of urinary podocyte-derived extracellular vesicles in swine with metabolic syndrome: Role of podocyte mitochondria
• Hypercholesterolemia impairs nonstenotic kidney outcomes after reversal of experimental renovascular hypertension
• Quantifying duration of proteinuria remission and association with clinical outcome in IgA nephropathy
• Renal Adiposity Does not Preclude Quantitative Assessment of Renal Function Using Dual-Energy Multidetector CT in Mildly Obese Human Subjects
• Alterations in genetic and protein content of swine adipose tissue-derived mesenchymal stem cells in the metabolic syndrome
• The metabolic syndrome alters the miRNA signature of porcine adipose tissue-derived mesenchymal stem cells
• Mesenchymal stem cell treatment for chronic renal failure
• Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells
• Urinary mitochondrial DNA copy number identifies renal mitochondrial injury in renovascular hypertensive patients undergoing renal revascularization: A Pilot Study
• Animal Models of Hypertension: A Scientific Statement From the American Heart Association
• Mesenchymal Stem Cell-Derived Extracellular Vesicles Improve the Renal Microvasculature in Metabolic Renovascular Disease in Swine
• Novel therapeutic strategies for renovascular disease
• Mitochondrial targeted peptides attenuate residual myocardial damage after reversal of experimental renovascular hypertension
• Senescent Kidney Cells in Hypertensive Patients Release Urinary Extracellular Vesicles
• Metabolic Syndrome Is Associated With Altered mRNA and miRNA Content in Human Circulating Extracellular Vesicles
• A Multicenter Randomized Controlled Trial of Rituximab versus Cyclosporine in the Treatment of Idiopathic Membranous Nephropathy (MENTOR)
• A mitochondrial permeability transition pore inhibitor improves renal outcomes after revascularization in experimental atherosclerotic renal artery stenosis
• Restoration of mitochondrial cardiolipin attenuates cardiac damage in swine renovascular hypertension
• Intrarenal fat deposition does not interfere with the measurement of single-kidney perfusion in obese swine using multi-detector computed tomography
• Stent revascularization restores cortical blood flow and reverses tissue hypoxia in atherosclerotic renal artery stenosis but fails to reverse inflammatory pathways or glomerular filtration rate
• The Micro-RNA Cargo of Extracellular Vesicles Released by Human Adipose Tissue-Derived Mesenchymal Stem Cells Is Modified by Obesity
• Oxidative stress and mitochondrial abnormalities contribute to decreased endothelial nitric oxide synthase expression and renal disease progression in early experimental polycystic kidney disease
• Mesenchymal stem cell-derived extracellular vesicles for kidney repair: Current status and looming challenges
• Extrarenal atherosclerotic disease blunts renal recovery in patients with renovascular hypertension
• Endothelial outgrowth cells shift macrophage phenotype and improve kidney viability in swine renal artery stenosis
• Acute kidney injury in patients with inactive cytochrome P450 polymorphisms
• Differences in GFR and tissue oxygenation, and interactions between stenotic and contralateral kidneys in unilateral atherosclerotic renovascular disease
• Diabetic Kidney Disease Alters the Transcriptome and Function of Human Adipose-Derived Mesenchymal Stromal Cells but Maintains Immunomodulatory and Paracrine Activities Important for Renal Repair
• Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles for Chronic Kidney Disease: Are We There Yet?
• Application of the International IgA Nephropathy Prediction Tool one or two years post-biopsy
• Metabolic syndrome alters expression of insulin signaling-related genes in swine mesenchymal stem cells
• Intrarenal modulation of NF-κB activity attenuates cardiac injury in a swine model of CKD: A renal-cardio axis
• Improving treatment decisions using personalized risk assessment from the International IgA Nephropathy Prediction Tool
• Adipose tissue remodeling in a novel domestic porcine model of diet-induced obesity
• Experimental coronary artery stenosis accelerates kidney damage in renovascular hypertensive swine
• Mitoprotection preserves the renal vasculature in porcine metabolic syndrome
• Mitochondrial targeted peptides preserve mitochondrial organization and decrease reversible myocardial changes in early swine metabolic syndrome
• Emerging concepts for patients with treatment-resistant hypertension
• Inflammatory and injury signals released from the post-stenotic human kidney
• Upregulated tumor necrosis factor-α transcriptome and proteome in adipose tissue-derived mesenchymal stem cells from pigs with metabolic syndrome
• Renal ischemia alters expression of mitochondria-related genes and impairs mitochondrial structure and function in swine scattered tubular-like cells
• MicroRNA and mRNA cargo of extracellular vesicles from porcine adipose tissue-derived mesenchymal stem cells
• Angiotensin receptor blockade has protective effects on the poststenotic porcine kidney
• Biomarkers of kidney injury and klotho in patients with atherosclerotic renovascular disease
• Mesenchymal stem cells protect renal tubular cells via TSG-6 regulating macrophage function and phenotype switching
• Urinary Mitochondrial DNA Copy Number Identifies Chronic Renal Injury in Hypertensive Patients
• Global epigenetic alterations of mesenchymal stem cells in obesity: the role of vitamin C reprogramming
• The metabolic syndrome modifies the mRNA expression profile of extracellular vesicles derived from porcine mesenchymal stem cells
• Renal fibrosis detected by diffusion-weighted magnetic resonance imaging remains unchanged despite treatment in subjects with renovascular disease
• Renal Revascularization Attenuates Myocardial Mitochondrial Damage and Improves Diastolic Function in Pigs with Metabolic Syndrome and Renovascular Hypertension
• Correction to: Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells (Cell Communication and Signaling, (2020), 18, 1, (124), 10.1186/s12964-020-00624-8)
• Loss of renal peritubular capillaries in hypertensive patients is detectable by urinary endothelial microparticle levels
• Renovascular Disease Induces Senescence in Renal Scattered Tubular-Like Cells and Impairs Their Reparative Potency
• Stem cell-derived extracellular vesicles for renal repair: Do cardiovascular comorbidities matter?
• Mitochondria: A pathogenic paradigm in hypertensive renal disease
• Obesity-induced mitochondrial dysfunction in porcine adipose tissue-derived mesenchymal stem cells
• Cardiac function in renovascular hypertensive patients with and without renal dysfunction
• Preserved endothelial progenitor cell angiogenic activity in African American essential hypertensive patients
• Mitoprotection attenuates myocardial vascular impairment in porcine metabolic syndrome
• Renal artery stenosis alters gene expression in swine scattered tubular-like cells
• Hemodynamic determinants of perivascular collateral development in swine renal artery stenosis
• Emerging paradigms in chronic kidney ischemia
• The emerging role of mitochondrial targeting in kidney disease
• Functional plasticity of adipose-derived stromal cells during development of obesity
• Role of Renal Sinus Adipose Tissue in Obesity-induced Renal Injury
• Metabolic Syndrome Interferes with Packaging of Proteins within Porcine Mesenchymal Stem Cell-Derived Extracellular Vesicles
• Perirenal Fat Promotes Renal Arterial Endothelial Dysfunction in Obese Swine through Tumor Necrosis Factor-α
• Enhancing Mitochondrial Health to Treat Hypertension
• Cardiac micro-RNA and transcriptomic profile of a novel swine model of chronic kidney disease and left ventricular diastolic dysfunction
• Mitochondrial injury and dysfunction in hypertension-induced cardiac damage
• Extracellular vesicles released by adipose tissue-derived mesenchymal stromal/stem cells from obese pigs fail to repair the injured kidney
• Micro-RNAS Regulate Metabolic Syndrome-induced Senescence in Porcine Adipose Tissue-derived Mesenchymal Stem Cells through the P16/MAPK Pathway
• Obesity-metabolic derangement preserves hemodynamics but promotes intrarenal adiposity and macrophage infiltration in swine renovascular disease
• Changes in glomerular filtration rate after renal revascularization correlate with microvascular hemodynamics and infilammation in swine renal artery stenosis
• Osteopontin: An emerging therapeutic target in uraemic vascular disease
• Addition of endothelial progenitor cells to renal revascularization restores medullary tubular oxygen consumption in swine renal artery stenosis
• Low-and high-molecular-weight urinary proteins as predictors of response to rituximab in patients with membranous nephropathy: A prospective study
• Chronic renovascular hypertension is associated with elevated levels of neutrophil gelatinase-associated lipocalin
• Mesenchymal Stem Cells Improve Medullary Inflammation and Fibrosis after Revascularization of Swine Atherosclerotic Renal Artery Stenosis
• Urinary albumin excretion patterns of patients with cast nephropathy and other monoclonal gammopathy-related kidney diseases.
• Renal transplantation in antineutrophil cytoplasmic antibody-associated vasculitis: A multicenter experience
• Humanin, a cytoprotective peptide, is expressed in carotid artherosclerotic plaques in humans
• Rituximab therapy in idiopathic membranous nephropathy: A 2-year study
• Renal ischemia alters the transcriptomic and epigenetic profile of inflammatory genes in swine scattered tubular-like cells
• Kidney Intrinsic Mechanisms as Novel Targets in Renovascular Hypertension
• Altered immune cell phenotypes within chronically ischemic human kidneys distal to occlusive renal artery disease
• Renovascular Disease and Mitochondrial Dysfunction in Human Mesenchymal Stem Cells
• Role of mitochondria in endogenous renal repair
• Dyslipidemia-induced renal fibrosis related to ferroptosis and endoplasmic reticulum stress
• Immune Rejection of Human Mesenchymal Stem Cells Compared to Extracellular Vesicles in Mice with Renal Artery Stenosis
• Renal ischemia alters the mRNA and miRNA profile of vasculature-related genes in scattered tubular-like cells from female pigs