Alexander Cole
Biologist (Bioavailability and ecotoxicology; Environmental sciences; Pollution and contamination; Environmental biotechnology)
Duluth, MN, USA
I am an environmental toxicologist with a strong background in biochemistry and microbiology. Over the past decade I have been fortunate to be part of multiple research teams. Experienced in field and laboratory techniques for in situ, in vivo and in vitro analyses; data management and in silico analyses; ontology and knowledge graphs; systematic literature review; research planning, funding, and implementation; public outreach; and interdisciplinary collaboration. Ability to provide situation analysis, creative solutions and establish good working relationships. Advocate for new approach methodologies (NAMs) for the reduction and refinement of animal testing and increased efficiency of chemical risk assessment.
I presently work for the U.S. Environmental Protection Agency at the Great Lakes Toxicology and Ecology Division. My current efforts are focused on the development and application of U.S. EPA’s Ecotoxicity Knowledgebase (ECOTOX; www.epa.gov/ecotox) to enhance the cross-compatibility of in silico tools for predicting mechanisms of toxicity such as the Adverse Outcome Pathway Wiki, Sequence Alignment to Predict Across Species Susceptibility Tool, and the Generalized Read Across tool.
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Publications
- Global occurrence of synthetic glucocorticoids and glucocorticoid receptor agonistic activity, and aquatic hazards in effluent discharges and freshwater systems
- Effects-Based Monitoring of Bioactive Chemicals Discharged to the Colorado River before and after a Municipal Wastewater Treatment Plant Replacement
- Effects-based monitoring of bioactive compounds associated with municipal wastewater treatment plant effluent discharge to the South Platte River, Colorado, USA
- Effects of Metformin and its Metabolite Guanylurea on Fathead Minnow (Pimephales promelas) Reproduction
- Assessing effects of aromatase inhibition on fishes with group-synchronous oocyte development using western mosquitofish (Gambusia affinis) as a model
- The Tissue‐Specific Eco‐Exposome: Differential Pharmaceutical Bioaccumulation and Disposition in Fish among Trophic Positions
- Comparative Endpoint Sensitivity of Bioanalytical Tools for Glucocorticoid Receptor Agonism Surveillance in Aquatic Matrices
- Deciphering Host–Parasite Interplay in Leishmania Infection through a One Health View of Proteomics Studies on Drug Resistance
- Comparative glucocorticoid receptor agonism: In silico, in vitro, and in vivo and identification of potential biomarkers for synthetic glucocorticoid exposure
- Bioaccumulation and Uptake Kinetics of Per- and Polyfluoroalkyl Substances in Pimephales promelas
- Inhibition of Fin Regeneration in Fathead Minnow (Pimephales promelas) by a Potent Synthetic Glucocorticoid and Development of Adverse Outcome Pathway 334
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Co-workers & collaborators
- BB
Brett Blackwell
- JC
Jenna E. Cavallin
- DV
Dan Villeneuve
- KJ
Kathleen Jensen
- DV
Daniel Villeneuve
- MK
Michael Kahl