Macroscopic and microscopic appearances of native organs.
A) Heart: Left panel, macroscopic appearance of heart (B18908). Arrow indicates macroscopic bleeding in the myocardium (B18908). Right panel, subendocardial hemorrhage within the myocardium as well as on the epicardial surface (H&E ×100). B) Lungs: Left panel, macroscopic appearance of lung in which there was patchy bleeding (B3208) (Table 5). Right panel, acute congestion, focal atelactasis, multiple thrombi with no features of inflammation (H&E ×200). C) Staining for platelets (CD41+) was positive in lungs, suggesting platelet aggregation and migration. This phenomenon was observed in lungs regardless of bleeding, but was present in other native organs only when bleeding had occurred (Table 6) (×100). D) Small intestine: Left panel, macroscopic hemorrhage in the wall of small intestine. Right panel, although the mucosa appeared normal, prominent submucosal hemorrhage was noted (B18908) (H&E ×100). E) Kidneys: Left panel, kidneys were macroscopically normal, except in one case (B18908) which showed small, patchy petechiae. Right panel, acute glomerular congestion associated with tubular and interstitial hemorrhage (H&E ×100). F) Lymph nodes: Although the macroscopic appearance was normal, lymph nodes in one case (B18508) showed hemorrhage in the hilar and medullary regions (H&E ×200).