Figure_1.tif (9.51 MB)
Necrosis of the renal cortex in 2K1C rats and preservation of the renal tissue in HPP593-treated 2K1C rats (H&E and PAS staining).
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posted on 2013-05-15, 10:52 authored by Larisa V. Fedorova, Komal Sodhi, Cara Gatto-Weis, Nitin Puri, Terry D. Hinds Jr, Joseph I. Shapiro, Deepak MalhotraIn 2K1C rats, renal architecture is preserved, in some cortical areas where injury has progressed dystrophic calcifications are present (asterisk). Necrotic tubular cells retain their cellular outlines, however their nuclei are lost due to ongoing karyolysis. In the clipped kidneys of HPP593-treated 2K1C rats some renal tubules appear to be intact (arrow). In tubules with dedifferentiated epithelium the lumen is narrowed and basement membranes are multilayered (arrowhead). Other tubules are dilated and filled with proteinaceous cast. Interstitium contains lymphoid infiltrate (star).
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BiochemistryBioenergeticshistologyModel organismsAnimal modelsratMolecular cell biologySignal transductionSignaling in cellular processesRedox signalingNuclear receptor signalingCell deathCellular stress responsesNephrologyChronic kidney diseaseTubulointerstitial diseaserenalcortex2k1cratspreservationhpp593-treatedpas
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