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FcγRll: Characterisation of novel Fc receptor interactions and a new receptor form.

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posted on 11.01.2018, 03:43 by JESSICA CLAIRE ANANIA
Leukocyte Fc receptors (FcR) bind to immunogloulins (Ig) to link the innate and humoral immune system to help balance the immune system and clear infections. We have characterised a novel FcR for IgG (FcγR) form, designated FcγRIIa3, which contains a 19 amino acid insert. This insert interacts with cytoskeletal structures allowing the receptor to be retained for longer periods of time at the cells surface upon activation, higher cell signalling which causes greater cellular activation. Therefore, individuals who express this FcγRIIa3 may be predisposed to pro-inflammatory disease.

History

Principal supervisor

Phillip Mark Hogarth

Additional supervisor 1

Bruce D. Wines

Year of Award

2018

Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Burnet Institute

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

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