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Delivery of Anti Cancer Drugs to Breast Cancer Cells using pH-sensitive Inorganic Nanoparticles

thesis
posted on 10.07.2020 by FITYA SYARIFA MOZAR
pH-sensitive inorganic nanoparticles have shown enormous potential as chemotherapeutic drug delivery carriers. Three different nanocrystals namely carbonate apatite (CA), strontium sulfite (SrSO3), and strontium fluoride (SrF2) were fabricated in this study and subsequently delivered to breast cancer cells after incorporation with selected anticancer drugs. These treatment effectivities were assessed both in vitro using human and mice breast cancer cell lines, as well as in vivo using tumor-bearing mice models. Biodegradability, versatility, cost-effective and easy fabrication technique gives these nanocrystals marked advantages compared to other conventional nanoparticles.

History

Principal supervisor

Ezharul Hoque Chowdhury

Additional supervisor 1

Rakesh Naidu

Year of Award

2018

Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Campus location

Malaysia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports

Exports