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Asian cobra venom neurotoxicity: an examination of the efficacy of antivenoms and identification of key toxins

thesis
posted on 2022-07-25, 07:07 authored by TAM MINH HUYNH

To increase our understanding of how snake venoms cause paralysis and the effectiveness of antivenom as a treatment, we tested the ability of antivenoms to reverse the paralytic effects of three Asian cobra venoms. Venoms can cause paralysis by targeting the nerve or the muscle to block their communication. We can categorise venoms based on where they act, and then investigate the effectiveness of antivenom against different types of paralytic venoms. We showed that antivenom can reverse the paralytic effects of the three Asian cobra venoms tested.

History

Principal supervisor

Wayne Hodgson

Additional supervisor 1

Anjana Silva

Additional supervisor 2

Geoff Isbister

Year of Award

2022

Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Pharmacology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences