Data and analysis scripts: psychological factors associated with painful vs. non-painful HIV-associated sensory neuropathy
Background & objectives
HIV-associated sensory neuropathy (HIV-SN) is a common, frequently painful complication of HIV. We investigated whether psychological factors associated with painful versus non-painful HIV-SN, and if pain and psychological factors affected quality of life (QoL). And, in the painful HIV-SN group only (secondary analysis), we investigated whether psychological factors associated with pain intensity.
We recruited 125 patients with painful HIV-SN and 72 patients with non-painful HIV-SN. We assessed anxiety and depression using the Hopkins Symptoms Checklist-25. Pain catastrophizing and QoL was assessed using the Pain Catastrophizing Scale and EQ-5D, respectively.
No included psychological factors were associated with having painful HIV-SN. Greater depressive symptoms and presence, but not intensity, of pain was independently associated with lower QoL. In addition, a greater depressive symptom score was associated with increased pain intensity.
Our findings demonstrate a high pain burden in this cohort, of which HIV-SN was only one part, and emphasises the importance of psychological factors, particularly depression, in the assessment of HIV-SN. Our data also confirm that results from studies in developed countries cannot be generalised to African cohorts.
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