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snpnet-Cox results
dataset
posted on 2020-05-26, 03:49 authored by Ruilin LiRuilin Li, Christopher Chang, Johanne Justesen, Yosuke TanigawaYosuke Tanigawa, Junyang Qian, Trevor J. Hastie, Manuel Rivas, Robert Tibshiranisnpnet-Cox is an efficient solver for large scale and high-dimensional Lasso Cox regression problems with genetic predictors. Here we provide its output on 306 time-to-event phenotypes from UK Biobank.
The names of the files are in the form (ukbcode).coefficients.tsv, where the ukbid is the UK Biobank code for the time-to-event phenotypes They contain the SNPs selected by snpnet-Cox as well as the corresponding coefficients. The file snpnetCox.map.tsv provides the number of cases and controls, the name, and the ICD 10 code of these phenotypes.
We built an interactive app based on these results. Its link is in the reference.
Please see our publication for more details.
Funding
Center for Multi- and Trans-ethnic Mapping of Mendelian and Complex Diseases
National Human Genome Research Institute
Find out more...SOFTWARE FOR LARGE-SCALE INFERENCE OF THE GENETICS OF LIFESTYLE MEASURES, BIOMARKERS, AND COMMON AND RARE DISEASES
National Human Genome Research Institute
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