Highlight of a Large-Scale In Situ Visualization of Raleigh-Taylor Instability with Ascent and VTK-m. The 97.8 billion element simulation ran across 16,384 GPUs on 4,096 Sierra Compute Nodes to guide the development of sub-grid models to capture instability effects with less computation. The visualization and analysis used the same resources as the simulation and scaled to the entire machine.