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Analysis of the consequences of short-term Nfat inactivation in ICN1-induced T-ALL.

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posted on 08.07.2021, 00:48 by Claire Catherinet, Diana Passaro, Stéphanie Gachet, Hind Medyouf, Anne Reynaud, Charlène Lasgi, Jacques Ghysdael, Christine Tran Quang

The Nfat-proficient and Nfat-deficient versions of T-ALL #21 were generated as described in Fig 1A. Mice were sacrificed when terminally ill, 2 days after the end of So and Tam treatments (1 and 2 in Fig 1A). (A) Leukemic burden (% tNGFR+ cells) in BM was analyzed by flow cytometry at the time mice were killed (data are represented as ± SEM; n = 3; Student’s t-test; ns: non-significant). (B) Apoptosis in leukemic cells described in (A) was analyzed by measuring caspase 3 activation by flow cytometry (data are represented as ± SEM; n = 3; Student’s t-test; ns: non-significant).

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