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Additional file 6 of Examining the relationship between maternal body size, gestational glucose tolerance status, mode of delivery and ethnicity on human milk microbiota at three months post-partum

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posted on 2020-07-21, 05:05 authored by Lauren LeMay-Nedjelski, James Butcher, Sylvia H. Ley, Michelle R. Asbury, Anthony J. Hanley, Alex Kiss, Sharon Unger, Julia K. Copeland, Pauline W. Wang, Bernard Zinman, Alain Stintzi, Deborah L. O’Connor
Additional file 6: Figure S2A-E. Visual representation of the association between maternal characteristics and milk microbiota beta-diversity (Bray-Curtis metric). Principal coordinate analysis (PCoA, Bray-Curtis dissimilarity) plots comparing microbiota composition based on (A) maternal glucose tolerance, (B) mode of delivery, (C) pre-pregnancy BMI, (D) 3-month post-partum BMI, and (E) ethnicity. PCoA using the Bray-Curtis dissimilarity showed that microbiota profiles separated based on pre-pregnancy BMI (R2 = 0.037, p = 0.031), even after adjustment for maternal glucose tolerance status, mode of delivery, DNA extraction batch, and PCR sequencing batch. No statistically significant findings were observed between beta-diversity and glucose tolerance, mode of delivery, 3-month post-partum BMI or ethnicity. Abbreviations: GDM, gestational diabetes mellitus, IGT, impaired glucose tolerance; CS, C-section.


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