Search for Antiviral Preparations in a Series of New Derivatives of N-Substituted Piperidines

This study focuses on the synthesis and biological evaluation of novel N-substituted piperidine derivatives, including carboxylic acids and fluorobenzoic or cyclopropanecarboxylic esters. Structural characterization was carried out using 1D and 2D NMR spectroscopy (COSY, HMQC, HMBC). Antiviral activity was evaluated in vitro against the influenza A/H1N1 virus using the MDCK cell model. Several compounds (notably 5d, 8, and 11) showed comparable or superior efficacy to commercial antivirals like Tamiflu and Rimantadine, with acceptable cytotoxicity profiles. These findings support the potential of these compounds as future anti-influenza agents.