insulin.pdf (4.81 MB)

The Air-Water Interface Stabilises Alpha-Helical Conformations of the Insulin B-Chain

preprint
revised on 10.07.2019 and posted on 10.07.2019 by David Cheung
Using enhanced molecular dynamics simulations the structure of the insulin B-chain was investigated at the air-water interface and in bulk solution. Significant differences in the conformational behaviour between these environments were found, with the air-water interface stabilising the formation of alpha-helical structures.

History

Email Address of Submitting Author

david.cheung@nuigalway.ie

Institution

National University of Ireland Galway

Country

Ireland

ORCID For Submitting Author

0000-0002-3994-2295

Declaration of Conflict of Interest

no conflict of interest

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