<p dir="ltr">This report examines the profound analogical relationship between John Wheeler's elegant formulation of Einstein's general relativity—"matter tells spacetime how to curve, and curved spacetime tells matter how to move"—and a comparable characterization of Darwin's evolutionary theory: "genetics tell an organism how to live, and the environment shapes the evolution of a species population." Both formulations reveal similar patterns of reciprocal causality that offer insights into the nature of fundamental scientific paradigms and their epistemological foundations.</p>