This article investigates the drag estimation of the AIRBUS A330-200, combining computational simulations with experimental data. The study focuses on key types of drag—parasitic, induced, and wave drag—across various flight conditions such as cruise and takeoff. Using computational fluid dynamics (CFD) and wind tunnel experiments, the research aims to enhance the accuracy of drag predictions and explore strategies for reducing drag to improve fuel efficiency. The findings offer insights into potential design and operational optimizations for the A330-200, contributing to more efficient aircraft performance.