Accessing Telomerase via Oxygen-Hypoxia Cycling.pdf

This paper proposes a non-genetic, reversible method for somatic cell reversion using controlled environmental modulation of oxygen and hypoxia. Drawing from embryonic development, we demonstrate that cellular identity is not fixed in genetic programming but dynamically regulated by oxygen tension. By mimicking the natural fetal transition from hypoxia to oxygen-rich states—where pluripotent stem cells differentiate into somatic cells—we theorize that cellular specialization results from a suppressive cascade, primarily mediated by oxygen-driven p53 activation. Reintroduction of hypoxia dismantles this cascade, restoring access to telomerase and shelterin stability. This framework offers a clean, biologically plausible alternative to gene-based reprogramming and has profound implications for regenerative medicine, oncology, and aging. The system is released freely into the public domain to ensure ethical development and equitable access to life-extending technologies.