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Spatial distribution of cells in Hodgkin Lymphoma

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posted on 22.10.2013, 12:19 by Tim Schäfer, Hendrik Schäfer, Jörg Ackermann, Norbert Dichter, Claudia Döring, Sylvia Hartmann, Martin-Leo Hansmann, Ina Koch

Here we present our current work on the analysis of a database of HL whole slide images. We performed pre-processing and identified regions of interest (ROI) that contain CD30-positive cells in the images as described before. A CellProfiler pipeline was used to detect and measure cells in the ROI. The cells were then classified using shape descriptors and stored in a database with their 2D coordinates. This allowed for a statistical analysis of the spatial distribution of HRS cells within the tissue.

 

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