High-throughput and Highly Sensitive Mpox Test with QuantiVirusTM MPXV Test Kit
Monkeypox (mpox) is a rare disease that is caused by infection with monkeypox (mpox) virus. This virus can spread to anyone through close, personal, often skin-to-skin contact. The mpox genome is a large single linear molecule of dsDNA, about 197 kilobase-pairs (kbp) in length. The genome consists of about 190 non-overlapping open reading frames (>180 bp long) containing 60 or more amino acid residues. There are two clades of Mpox: the West African clade (clade II) and the Congo Basin clade (clade I). The QuantiVirus™ MPXV Test Kit [FDA EUA and CE/IVD] detects DNA from both clade I and clade II of MPXV in lesion swab specimens (i.e., swabs of acute pustular or vesicular rash). It uses a fluorescent probe with specific primer sets to detect the J2L and B6R genes within the genome of MPXV. Primers and probe for an internal control, RNase P are also integrated in the assay to validate the assay quality.
