Fatty Acids Produced by De Novo Lipogenesis (DNL) of Refined Carbohydrates are Associated with Worsening of Metabolic Syndrome (MetS) Components: The Prospective Metabolism and Islet Cell Evaluation (PROMISE) Cohort
poster
posted on 2017-06-16, 21:00 authored by Luke JohnstonLuke Johnston, Ravi Retnakaran, Stewart B. Harris, Zhen Liu, Richard P. Bazinet, Anthony J. HanleyPoster for the 77th Scientific Sessions of the American Diabetes Association (2017) in San Diego, USA. Abstract below:
While triglycerides (TG) are a part of the MetS, the impact of the specific TG fatty acid (TGFA) composition on metabolic functioning is not well known, especially over time. Our aim was to examine the longitudinal association of serum TGFA composition with MetS components.
Adults at risk for diabetes had 3 visits over 6 yrs (n=477). TGFA (mol%) was measured at baseline. Outcomes were MetS components waist, HDL, clinical TG, fasting glucose (FG), and mean arterial pressure (MAP). We used partial least squares (PLS) to extract TGFA clusters. We evaluated longitudinal associations using generalized estimating equations (GEE) adjusted for time, sex, age, and ethnicity.
Four TGFA loaded positively on PLS cluster 1 (C1): 14:0, 16:0, 14:1n-7, and 16:1n-7 (Fig. A). TGFA were distributed evenly on cluster 2 (C2). In GEE models (Fig. B), higher C1 associated with lower HDL and higher FG, MAP, TG, and waist consistently over the 6 years. While higher C2 similarly associated with higher FG, MAP, and waist, it associated with higher HDL and lower TG.
We found that a higher proportion of 4 TGFA strongly predicted worsening of MetS components. These 4 TGFA are products of DNL from refined carbohydrates. Our results provide further evidence to support the harmful impact of refined carbohydrates on metabolic health.
While triglycerides (TG) are a part of the MetS, the impact of the specific TG fatty acid (TGFA) composition on metabolic functioning is not well known, especially over time. Our aim was to examine the longitudinal association of serum TGFA composition with MetS components.
Adults at risk for diabetes had 3 visits over 6 yrs (n=477). TGFA (mol%) was measured at baseline. Outcomes were MetS components waist, HDL, clinical TG, fasting glucose (FG), and mean arterial pressure (MAP). We used partial least squares (PLS) to extract TGFA clusters. We evaluated longitudinal associations using generalized estimating equations (GEE) adjusted for time, sex, age, and ethnicity.
Four TGFA loaded positively on PLS cluster 1 (C1): 14:0, 16:0, 14:1n-7, and 16:1n-7 (Fig. A). TGFA were distributed evenly on cluster 2 (C2). In GEE models (Fig. B), higher C1 associated with lower HDL and higher FG, MAP, TG, and waist consistently over the 6 years. While higher C2 similarly associated with higher FG, MAP, and waist, it associated with higher HDL and lower TG.
We found that a higher proportion of 4 TGFA strongly predicted worsening of MetS components. These 4 TGFA are products of DNL from refined carbohydrates. Our results provide further evidence to support the harmful impact of refined carbohydrates on metabolic health.
