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pH-triggered poly(ethylene glycol) nanogels prepared through orthoester linkages as potential drug carriers

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journal contribution
posted on 2018-01-03, 14:44 authored by Guanqing Yang, Shengxiang Fu, Xin Wang, Jun Wang, Rupei Tang

The new acid-labile poly(ethylene glycol) (PEG) nanogels were prepared by copolymerization of a new crosslinking agent containing orthoester groups (OEAM) and methoxypolyethylene glycol acrylate (MPEGAC). DOX was loaded into PEG nanogels with a loading content of 18.2%, which was highly desirable for targeted cancer therapy without premature drug release in neutral environment. The cellular uptake and cytotoxicity of DOX-loaded PEG nanogels were measured using SH-SY5Y and HepG2 cells. Tumor penetration and antitumor activity were investigated using SH-SY5Y tumor-like spheroids. All results demonstrate that the pH-sensitive PEG nanogels may be used as potential drug carriers for chemotherapy.

Funding

This work is supported by the National Natural Science Foundation of China (Nos. 51503001 and 51603001), the Natural Science Foundation of Anhui Province of China (No. 1408085MB26), the Nature Science Research Programme of the Education Office of Anhui Province (No. KJ2016A030), the Research Foundation for Key Program of Education Department of Anhui Province of China (No. KJ2016A030), the Doctor Research Foundation of Anhui University (No. J10113190075), and the Academic and Technology Introduction Project of Anhui University (AU02303203).

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