Fig 1.tif (355.49 kB)
pGSK3/GSK3 ratio in BTBR-WT and ob/ob mice.
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posted on 2017-12-15, 18:40 authored by Theun de Groot, Lars Damen, Leanne Kosse, Mohammad Alsady, Rosalinda Doty, Ruben Baumgarten, Susan Sheehan, Johan van der Vlag, Ron Korstanje, Peter M. T. DeenKidneys from 24-week old female BTBR-WT and -ob/ob mice were isolated and protein lysates were immunoblotted for pGSK3 and GSK3. Representative immunoblots for WT and ob/ob mice for (A) GSK3 and (B) pGSK3 are depicted. Corresponding densitometric analysis of (C) total GSK3 abundance and (D) pGSK3/GSK3 ratio (n = 9 per group). **p<0.01. Cm, Coomassie.
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GSK 3 inhibition increases glucose uptakeblood lithium levelsdiabetes mellitusNGALblood glucose levelsnephropathyLi -40 dietGSK 3 inhibitionGSK 3 inhibitorimmunoglobulin G levelslithium attenuates non-fasting blood glucose levelsalbuminBTBR-WTtubule brush borderglomerulosclerosiBTBRnon-fasting blood glucose levelsimmunoglobulin G contentkidney injury
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