<p>Background: Adenovirus is associated with
respiratory tract infections in children worldwide. However, there is insufficient
data about adenovirus infections in Egyptian children and the genotypes present
in this infection.</p>
<p>Objective: The aim of the present study was to investigate
the prevalence of adenovirus and its genotypes in respiratory tract infection
in children by real time PCR.</p>
<p>Methods:
The study was a cross- sectional
study that included 100 children complaining of respiratory tract infections
signs and symptoms. Laboratory investigation for adenovirus included real time
polymerase chain reaction and genotypes detection by multiplex polymerase chain
reaction (PCR)). </p>
<p>Results: Adenovirus was detected by PCR for fiber gene in 11%
with genotype 3 in 6 samples (54.5%) and genotype 7 in 5 samples (45.5%)
positive samples for adenovirus by Multiplex PCR. The main presenting symptoms and signs in
children with adenovirus detected by PCR were cough, fever, wheezing and croups
(90.9%,
81.1%, 63.6%, and 63.6% respectively). The diagnosis in children with
adenovirus was pneumonia in 72.7% and bronchitis in 27.7%. There were
statistically insignificant differences in demographic, clinical and
hematological parameters between children with adenovirus and children negative
to adenovirus by PCR. </p>
<p>Conclusion: The clinical characteristics of respiratory
infections with adenovirus vary upon the age of the patients and the immune
status. Therefore, there is a requirement for extensive study of adenovirus in
respiratory infections in children with different ages and immune status.</p>
<p>Keywords: Children, Respiratory
infection, Pneumonia, Adenovirus genotype 7, adenovirus genotype 3, Multiplex
PCR</p>
<p> </p>
<p><b> </b></p>
<p><b> </b></p>
<p><b> </b></p>
