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p63 in epithelial development.

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posted on 12.11.2008, 16:19 by Eleonora Candi, Rita Cipollone, Pia Rivetti de Val Cervo, Stefania Gonfloni, Gerry Melino, Richard A. Knight
The epidermis, the outer layer of the skin composed of keratinocytes, is a stratified epithelium that functions as a barrier to protect the organism from dehydration and external insults. The epidermis develops following the action of the transcription factor p63, amember of the p53 family of transcription factors. The Trp63 gene contains two promoters driving the production of distinct proteins, one with an N-terminal transactivation domain (TAp63) and one without (ΔNp63), although their relative contribution to epidermal development is not clearly established. Trp63 mutations are involved in the pathogenesis of several human diseases, phenotypically characterized by ectodermal dysplasia. In this review, we summarize the current advances that have been made in understanding the role of p63 in epidermal morphogenesis.
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Citation

Cellular and Molecular Life Sciences, 2008, 65 (20), pp. 3126-3133.

Published in

Cellular and Molecular Life Sciences

Publisher

Springer Verlag

issn

1420-682X

Available date

12/11/2008

Publisher version

http://link.springer.com/article/10.1007/s00018-008-8119-x

Notes

This is the author's final draft of the paper published as Cellular and Molecular Life Sciences, 2008, 65 (20), pp. 3126-3133. The original publication is available at www.springerlink.com. Doi: 10.1007/s00018-008-8119-x

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en

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