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nSides: An interactive drug--side effect gateway

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journal contribution
posted on 2017-10-10, 02:15 authored by Rami VanguriRami Vanguri, Joseph RomanoJoseph Romano, Tal Lorberbaum, Choonhan Youn, Victor Nwankwo, Nicholas TatonettiNicholas Tatonetti
Adverse drug events are a leading cause of morbidity and mortality around the world. Regulatory agencies, such as the Food and Drug Administration (FDA), maintain large collections of adverse event reports. These spontaneous reporting systems provide an opportunity to retrospectively study drug effects from patient population data. To make our results more accessible, we present a gateway to a new database of drug interactions (nSides) developed using the FDA Adverse Event Reporting System. Side effects for a variety of drugs and drug interactions are presented. Additionally, for high order drug combinations, with the support of the Science Gateway Community Institute's Extended Developer Support, we develop a novel system to request new models to be generated using the Open Science Grid on-demand.