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cis-mQTLs with SNPs in moderate LD (r2>0.4) with the genetic variant associated to the chronic Chagas cardiomyopathy.

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posted on 2021-10-29, 17:37 authored by Desiré Casares-Marfil, Martin Kerick, Eduardo Andrés-León, Pau Bosch-Nicolau, Israel Molina, Javier Martin, Marialbert Acosta-Herrera

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GWAS loci associated with Chagas cardiomyopathy influences DNA methylation levels
PLOS Neglected Tropical DiseasesPLOS Neglected Tropical Diseases

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relevant interactions correlatedfalse discovery ratediv >< pchronic cardiac formwide association studymethylation quantitative traitgwas leading variantfdr ]< 0chromosome 11 associated647 dnam sites20 asymptomatic individuals>- mqtls mappedasymptomatic individuals>- mqtlsgenetic association>- mqtlsac3d1 </recent genomepreviously reportedprevious studiesprevious gwaspotentially modulatepola2 </plaat3 </novel genesloci </inflammatory responsehematological traitsfunctional relevancefindings supportdna methylationcould playcis </chagas diseasechagas cardiomyopathyccdc88b </

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