pone.0297191.s001.pdf (567.24 kB)
POR haplotype frequencies in 68 dog breeds and mixed breed dogs.
journal contribution
posted on 2024-02-01, 18:40 authored by Stephanie E. Martinez, Amit V. Pandey, Tania E. Perez Jimenez, Zhaohui Zhu, Michael H. CourtPOR haplotype frequencies in 68 dog breeds and mixed breed dogs.
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substrate dependent mannerpoor drug metabolismgene variants associatedforming four allelesessential redox partnercytochrome c reductionallele frequencies ),65 &# 821134 &# 821172 %) comparedpor protein variantscyp2d15 enzyme kineticscyp2d15 enzyme functiondiv >< pcyp2d15 protein expressionpor protein expressionreference ), por570glu ), porprotein flexibilityenzyme activity37 %)cyp2d15 ).versus porrecombinant porpor variantxlink ">vivo study objectivessignificantly reducedscottish deerhoundssalt bridgeresults indicatep450 oxidoreductaseleast onelargely restrictedinsect cellsexpressed alonedog breedsbupropion oxidation2b11 substrates
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