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N-containing compounds from Periplaneta americana and their activities against wound healing

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journal contribution
posted on 29.03.2018, 11:47 by Yong-Ming Yan, Bin Xiang, Hong-Jie Zhu, Jing-Jing Qi, Bo Hou, Fu-Neng Geng, Yong-Xian Cheng

Three new compounds, periplanamides A (1) and B (2), periplanpyrazine A (3), a new naturally occurring compound salicyluric acid methyl ester (6), and seventeen known compounds were isolated from the medicinal insect Periplaneta americana. The structures of the new compounds were elucidated on the basis of spectroscopic methods. The absolute configurations of 2 were assigned by computational methods. Biological activities of these isolates except 1, 9, 11, and 13 toward nitric oxide (NO) production, cell proliferation in HDFs, cell migration and angiogenesis in HUVECs were evaluated.