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(M)- and (P)‑Bicelaphanol A, Dimeric Trinorditerpenes with Promising Neuroprotective Activity from Celastrus orbiculatus

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journal contribution
posted on 26.04.2013, 00:00 authored by Luo-Yi Wang, Jian Wu, Zhuo Yang, Xu-Jie Wang, Yan Fu, Shuang-Zhu Liu, Hong-Min Wang, Wei-Liang Zhu, Hai-Yan Zhang, Wei-Min Zhao
(M)-Bicelaphanol A (1) and (P)-bicelaphanol A (2), two unprecedented dimeric trinorditerpenes existing as atropisomers, together with their monomer celaphanol A (3), were isolated from the root bark of Celastrus orbiculatus. The structures and absolute configurations of 1 and 2 were determined by spectroscopic and single-crystal X-ray diffraction analyses. Compound 1 exhibited a significant in vitro neuroprotective effect against a hydrogen peroxide-induced cell viability decrease in PC12 cells at 1 μM, while compounds 2 and 3 showed such effects at 10 μM.