<b>Sustained Remission and Prevention of Psoriasis Relapse by a 10% Lavandula Oil Ointment in Rats with Imiquimod-Induced Dermatitis</b>

<p dir="ltr"><b>Sustained Remission and Prevention of Psoriasis Relapse by a 10% Lavandula Oil Ointment in Rats with Imiquimod-Induced Dermatitis</b> <b>Abstract:</b></p><p dir="ltr"><a href="" target="_blank"><b>Background</b></a>: Psoriasis is a chronic skin condition that affects patients and the healthcare system. Treatment options may vary because some issues are not fully addressed. Additionally, introducing a new natural treatment offers excellent potential for safety and effectiveness compared to traditional treatment methods.</p><p dir="ltr"><b>Objective: </b>This study investigated the efficacy of an ointment containing 10% lavender oil in treating psoriasis-like skin inflammation induced by imiquimod in rats.</p><p dir="ltr"><b>Methods: </b>Using a randomized controlled animal model, rats were treated with a 5% imiquimod ointment to induce psoriasis. We measured redness, skin thickness, and scaling scores in rats to evaluate the effectiveness of Lavandula oil ointment in managing psoriasis. Additionally, some psoriasis-related cytokine levels (TNF-α, IL-17, IL-23, and TGF-β) were assessed. Treatments were withheld during the last five days of the 20-day study period<b>.</b></p><p dir="ltr"><b>Results: </b>The study found that, topically, rats given lavender oil ointment had lower levels of TNF-α, IL-17, and IL-23 throughout the experimental period. The study also shows that rats treated with lavender oil ointment had significantly lower redness, thickness, and scaling scores compared to the control group. According to the study, the lavender oil ointment-treated rats showed no psoriatic lesions throughout the study, even after treatment was discontinued for 5 days. In contrast, the clobetasol-treated rats continued to develop psoriatic lesions over the five days leading up to the study's end<b>.</b></p><p dir="ltr"><b>Conclusion: </b>Study outcomes show that topical lavender oil consistently and effectively healed imiquimod-induced psoriasis lesions in rats. The ointment's ability to reduce cytokine levels, including TNF-α, IL-17, and IL-23, may explain its antipsoriatic effects.</p>