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Download fileβ‑Cyclodextrin–NHC–Gold(I) Complex (β-ICyD)AuCl: A Chiral Nanoreactor for Enantioselective and Substrate-Selective Alkoxycyclization Reactions
journal contribution
posted on 08.05.2020, 19:08 authored by Coralie Tugny, Natalia del Rio, Mehdi Koohgard, Nicolas Vanthuyne, Denis Lesage, Kajetan Bijouard, Pinglu Zhang, Jorge Meijide Suárez, Sylvain Roland, Etienne Derat, Olivia Bistri-Aslanoff, Matthieu Sollogoub, Louis Fensterbank, Virginie Mouriès-MansuyNHC-capped
β-cyclodextrin (β-ICyD) was used as a ligand
for gold-catalyzed alkoxycyclization reactions. The cavity was found
to be responsible for a triple selectivity: (i) the asymmetric shape
of the cavity of β-ICyD induced highly stereoselective cyclizations,
(ii) the shape of the interior favored the formation of a six-membered
ring in the absence of a nucleophile, and finally, (iii) the encapsulation
of the metal inside the cavity disfavored the addition of sterically
hindered alcohols. Highly enantioselective and substrate-selective
alkoxycyclizations of enynes are therefore promoted by the cavity-based
molecular reactor (β-ICyD)AuCl.