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β‑C(sp3)–H Arylation of α‑Hydroxy Acid Derivatives Utilizing Amino Acid as a Directing Group

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journal contribution
posted on 18.12.2015, 00:00 authored by Tetsuya Toba, Yi Hu, Anh T. Tran, Jin-Quan Yu
The Pd­(II)-catalyzed arylation of unactivated β-C­(sp3)–H bonds in α-hydroxy aliphatic acid with a variety of aryl iodides was developed utilizing an amino acid auxiliary as a directing group. This protocol provides access to biologically active β-arylated-α-hydroxy acid derivatives.