Ultrasensitive Chemiresistive Gas Sensor Can Diagnose Asthma and Monitor Its Severity by Analyzing Its Biomarker H₂S: An Experimental, Clinical, and Theoretical Study

Asthma is a chronic disease characterized by recurrent attacks of breathlessness and wheezing, which vary in severity and frequency from person to person. H₂S is considered as the biomarker of asthma. Here, an ultrasensitive chemiresistive H₂S gas sensor based on a γ-Bi₂MoO₆–CuO heterostructure with a detection limit of 5 ppb has been fabricated. It can distinguish asthmatic patients from healthy people roughly by analyzing the exhaled breaths of 28 asthmatic patients and 28 healthy people, suggesting that the sensor can be used to assist physicians in the diagnosis of asthma. Pathologically, it is discovered by this sensor that with the relief of asthma, the concentration of H₂S in one’s exhaled breath gradually increases. This subtle concentration variation of H₂S can be accurately detected, indicating that this sensor can be used in the asthma severity monitoring too. Physical models have been built by first-principles calculation to reveal the causes of the sensor’s ultrasensitivity. The stable adsorption of H₂S on the surface of CuO results in massive charge transferring and the appearance of the defect states, which play the major role in the ultrasensitivity of the sensor. Upon integrating this sensor with circuits, the cheap, smart, and portable H₂S sensing device can be obtained, which can make asthmatic patients’ access to this device easy and make the severity monitoring of asthma convenient, especially for children and the aged.