Two new sesquiterpene glycosides from the stems of Dendrobium henanense and their anti-inflammatory activity

Two new sesquiterpene glycosides, 8α,12,15β-trihydroxycopacamphan-15-O-β-D-glucopyranoside (1) and dendrobiumane C-11-O-β-D-glucopyranoside (2), along with three known terpenoids (3-5) were isolated from the aerial stems of Dendrobium henanense. Their structures were elucidated based on NMR-spectroscopic and HR-MS analyses. All compounds could reduce the levels of NO, TNF-α and IL-1β in LPS-induced RAW264.7 cells with IC₅₀ values ranging from 10.37 to 34.55 µΜ.