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Two new nor-sesquiterpenoids from Fusarium tricinctum, an endophytic fungus isolated from Ligusticum chuanxiong

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journal contribution
posted on 2020-01-25, 07:19 authored by Yu-Mei Cao, Da-Le Guo, Meng-Ying Jin, Lu Tan, Tian-Long Yang, Fang Deng, Yu-Cheng Gu, Xiao-Hua Li, Zhi-Xing Cao, Yun Deng

As part of our search for compounds with cytotoxicity from endophytes of traditional Chinese medicines, two novel nor-sesquiterpenoids (12) with a new skeleton containing a tetrahydrofuran moiety were isolated form a rice medium of Fusarium tricinctum, an endophytic fungus isolated from the root of Ligusticum chuanxiong. The structures of these two previously undescribed compounds were elucidated by interpretation of the spectroscopic evidences including NMR correlations as well as MS data. The absolute configurations of these two compounds were confirmed by TD-DFT-ECD calculations. An MTT assay indicated that compound 1 exhibited moderate cytotoxic activity against MV4-11 with an IC50 value of 22.29 μM.


This research was supported by Sichuan Provincial Youth Science and Technology Innovation Team under Grant [2016TD0006, 2015TD0028]; China Postdoctoral Science Foundation under Grant [2017M622985]; Project of Sichuan Administration of Traditional Chinese Medicine [2018HJZX015].